25 | | | | | Ser-Arg | Yes | SM, P, NEU-P.POS | LRR3 | | B, C |

28 | | | 0.07 | | Leu-Trp | | NP, NEU-P, NEU | LRR3 | | A, D |

| | | | | Leu-Pro | | NP, NEU-SM, NP, NEU | | | |

45 | | | 0.16 | | Thr-Ile | Yes | SM, P, NEU-NP, NEU | LRR4 | | A, F |

104 | | | 0.17 | | Leu-Val | | NP, NEU-NP, NEU | LRR6 | | |

| | | | | Leu-Ser | | NP, NEU-SM, P, NEU | | | |

128 | | 0.875 | | | Glu-Pro | | P, NEG-SM, NP, NEU | LRR7 | | D |

133 | | 0.723 | | | Asn-Lys | | SM, P, NEU-P, POS | LRR7 | | G |

139 | | 0.708 | | | Gly-Glu | | SM, NP, NEU-P, NEG | LRR8 | Adjacent to site involved in interaction with MD2 | G |

149 | | 0.565 | | | Ser/Leu -Thr | | SM, P, NEU/NP, NEU -SM, P, NEU | LRR8 | | G |

150
| 0.995 | | | 228.23 | His-Arg | Yes | P, POS-P, POS | LRR8 | | A, B, C |

| | | | | His-Asp | | P, POS-SM, P, NEG | | | |

177 | | | | 61.94 | Asn-Thr Asn/Thr -Ile Asn-Lys Ile-Asn | | SM, P, NEU-SM, P, NEU SM, P, NEU/SM, P, NEU -NP, NEU SM, P, NEU-P, POS NP, NEU-SM, P, NEU | LRR9 | Adjacent to site involved in ligand binding and interaction with MD2 | A, C, G |

179
| 0.992 | | 0.07 | 647.96 | Lys-Glu Glu-Gln Glu/Lys- Gln | Yes | P, POS-P, NEG P, NEG-P, NEU P, NEG/P, POS-P, NEU | LRR9 | | A, C, F |

183
| | | 0.12 | 51.06 | Arg-Ser Arg-Thr | | P, POS-SM, P, NEU P, POS-SM, P, NEU | LRR9 | | C, D |

204 | | | | | Glu-His | Yes | P, NEG-P, POS | LRR10 | | A, D |

207
| 1.000 | | 0.08 | 1563.58 | Gly/Lys -Arg Arg-Lys Arg-Thr Lys-Arg | | SM, NP, NEU/P, POS -P, POS P, POS-P, POSP, POS-SM, P, NEU P, POS-P, POS | LRR10 | | A, G, C, E |

212 | | | | | Leu-Val | Yes | P, POS-NP, NEU | LRR10 | | A, B |

221 | | | 0.1 | | Val-Met | Yes | NP, NEU-NP, NEU | LRR11 | | C, D, F |

228
| 0.994 | | 0.15 | 544.88 | Asp/Ser/Cys -Asn Asp-Asn | | SM, P, NEG/SM, P, NEU/SM, NP, NEU -SM, P, NEU SM, P, NEG-SM, P, NEU | LRR11 | | A, G |

230 | 0.978 | | | | Gly/Glu/Asp -Arg Asp-His | | SM, NP, NEU/P, NEG/SM, P, NEG -P.POS SM, P, NEG-P, POS | LRR11 | | A, E |

239 | | | | 50.32 | Cys-Tyr | Yes | SM, NP, NEU-P, NEU | LRR12 | | B, D, G |

247
| | | 0.14 | 86.14 | Ile-Thr Thr-Ile | | NP, NEU-SM, P, NEU SM, P, NEU-NP, NEU | LRR12 | Adjacent to site involved in interaction with ligand binding | C, G |

*250*
^{b}
| 0.936 | | | | Asp/Ala -Lys Asp/Lys/Ala -Asn Asn-Lys | | SM, P, NEG/SM, NP, NEU -P, POS SM, P, NEG/P, POS/SM, NP, NEU -SM, P, NEU SM, P, NEU-P, POS | LRR12 | Ligand binding | A, E, G |

265 | | | | | Phe-Leu | Yes | NP, NEU-NP, NEU | LRR13 | | B, E |

272
| 0.997 | | 0.13 | 188.28 | Gly/Asp- His Gly-His His-Gly | | SM, NP, NEU/SM, P, NEG-P, POS SM, NP, NEU-P, POS P, POS-SM, NP, NEU | LRR13 | Adjacent to site involved in interaction with ligand binding | A, C |

280
| 0.952 | | 0.18 | 191.07 | Glu-Ala Gln/Glu- Ala | Yes | P, NEG-SM, NP, NEU P, NEU/P, NEG-SM, NP, NEU | LRR13 | | A, B, E |

302 | | 0.624 | | | His-Arg | | P, POS-P.POS | LRR14 | | D |

304 | | | | 55.05 | Asp-Asn Asn-Pro | | SM, P, NEG-SM, P, NEU SM, P, NEU-SM, NP, NEU | LRR14 | | G |

324
| 0.996 | | | 301.87 | Asn-Ser Asn-Lys Gly-Asn | | SM, P, NEU-SM, P, NEU SM, P, NEU-P, POS SM, NP, NEU-SM, P, NEU | LRR15 | Adjacent to site involved in interaction with ligand binding (hydrogen bond) | C, E, G |

342 | | | | 53.56 | Asn-Ser Asn/Ser- Thr | | SM, P, NEU-SM, P, NEU SM, P, NEU/SM, P, NEU-SM, P, NEU | LRR16 | Adjacent to site involved in interaction with ligand binding (hydrogen bond) | A |

351 | | | | 0.17 | Ile/Ala-Val | | NP, NEU/SM, NP, NEU-NP, NEU | LRR16 | Adjacent to site involved in interaction with ligand binding (hydrophobic interaction) | G |

368 | | 0.576 | | | Ile-Thr | | NP, NEU-SM, P, NEU | LRR17 | Adjacent to site involved in interaction with ligand binding (hydrophobic interaction) | G |

404 | | | | 0.08 | Leu-Met | | NP, NEU-NP, NEU | LRR18 | | C |

408 | | | | | Ile-Thr | Yes | NP, NEU-SM, P, NEU | LRR19 | | A, G |

409 | | | | 0.19 | Leu/Ile/Phe -Val | | NP, NEU/NP, NEU/NP, NEU -NP, NEU | LRR19 | | A |

482 | | | | 0.16 | Ser/Trp- Phe Phe/Ser/Trp -Leu | | SM, P, NEU/P, NEU-NP, NEU NP, NEU/SM, P, NEU/P, NEU -NP, NEU | LRR22 | | A |

542 | 0.903 | | | | Met-Thr | Yes | NP, NEU-SM, P, NEU | LRRCT | | A, D |

551 | 0.938 | | | | Ile-Val Val-Ile | Yes | NP, NEU-NP, NEU NP, NEU-NP, NEU | Transmembrane | | B, F |

559 | | | | 0.16 | Val-Ala | | NP, NEU-SM, NP, NEU | Transmembrane | | G |

690 | | 0.564 | | | Arg-Gln | | P, POS-P, NEU | TIR | | D |

740 | | 0.790 | | | Glu-Asp | | P, NEG-SM, P, NEG | TIR | | G |

742 | | 0.697 | | | Asn-Arg | | SM, P, NEU-P, POS | TIR | | G |

743 | | | | 0.18 | Gln-Glu | | P, NEU-P, NEG | TIR | | A, F |