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Table 4 Over- and under-represented (italics) GO terms when duplicated genes are compared against singleton genes.

From: Duplicability of self-interacting human genes

Biological processes

GO IDs

Term

Obs.

Mean

S. D.

Z score

p-valuea

GO:0007154

cell communication

2009

1819.3

17.5

10.8

5.86E-27

GO:0006139

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

1446

1630.6

16.6

-11.1

4.08E-25

GO:0009058

biosynthetic process

1522

1650.6

17.0

-7.6

2.21E-12

GO:0050789

regulation of biological process

3130

3001.9

18.3

7.0

5.91E-11

GO:0007275

multicellular organismal development

1346

1241.1

15.8

6.7

1.76E-10

GO:0032501

multicellular organismal process

787

712.5

12.4

6.0

2.34E-08

GO:0022904

respiratory electron transport chain

3

14.9

1.9

-6.2

1.45E-06

GO:0043170

macromolecule metabolic process

2628

2726.8

18.2

-5.4

1.72E-06

GO:0030154

cell differentiation

726

673.2

12.1

4.4

3.02E-04

GO:0007610

behavior

218

189.6

7.1

4.0

3.39E-04

GO:0006928

cell motion

300

267.4

8.3

3.9

6.67E-04

GO:0009056

catabolic process

452

487.6

11.0

-3.2

1.70E-02

GO:0005634

nucleus

1

5.1

1.2

-3.4

4.85E-02

GO:0016787

hydrolase activity

1

5.1

1.2

-3.4

4.85E-02

Molecular Function

GO IDs

Term

Obs.

Mean

S. D.

Z score

p -value a

GO:0005488

binding

2905

2686.899

18.3

11.9

3.85E-29

GO:0004872

receptor activity

714

608.911

12.3

8.6

2.06E-19

GO:0016301

kinase activity

496

420.462

10.0

7.5

4.99E-14

GO:0015267

channel activity

203

159.644

6.6

6.6

1.28E-12

GO:0015075

ion transmembrane transporter activity

300

247.312

8.1

6.5

2.48E-11

GO:0004871

signal transducer activity

315

265.132

8.2

6.1

2.76E-09

GO:0003676

nucleic acid binding

1211

1290.829

16.5

-4.8

3.31E-05

GO:0016787

hydrolase activity

870

813.748

13.8

4.1

7.61E-04

GO:0045182

translation regulator activity

36

51.717

3.6

-4.3

2.28E-03

GO:0003774

motor activity

68

55.557

3.7

3.4

1.09E-02

GO:0016874

ligase activity

138

161.46

6.4

-3.7

1.21E-02

  1. a The estimated P values were adjusted by Bonferroni correction.