Exploring the HME and HAE1 efflux systems in the genus Burkholderia

Table 1 Consensus sequences of RND proteins according to Putman at al. (2000) [44].

MOTIF		CONSENSUS SEQUENCES
A	Old	G x s x v T v x F x x g t D x x x A q v q V q n k L q x A x p x L P x x V q x q g x x v x k
	Proposed	G x a x i t x t F x x g t d x d x A x x x V q x x x x x a x x x L P x x v x x p x x x x x x
B	Old	a l v l s a V F l P m a f f g G x t G x i y r q f s i T x v s A m a l S v x v a l t l t P A l c A
	Proposed	t l v l x a V F v P x a f x x G x x G x l f r x f A x t x a x a x x x S x x x a l t L x P a L c a
C	Old	x x x G k x l x e A x x x a a x x R L R P I L M T s L a f i l G v l P l a i a t G x A G a
	Proposed	x x x G x x p x x A x x e A a x l R l R P I l M T x l A x x l G x x P L a x x x G - a G s
D	Old	S i N t l T l f g l v l a i G L l v D D A I V v V E N v e R v l a e
	Proposed	s i N x l s L x g l v L A i G i l V D D A I V v v E N v e R x x x E

Table reported the previously individuated and the new proposed consensus sequence. X indicates any amino acid, capital letters show amino acids most frequently observed in a given position in more than 70% of the transport proteins, and lowercase letters represent amino acid occurring in at least than 40% of RND amino acid sequences.

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