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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

Figure 2

Alignment of IL4 protein sequences from mammalian lineages. Site 1, site 2 and site 3 epitope residues important for interaction with IL4Rα, γc and IL13Rα1 are colored red, blue and magenta, respectively. M. musculus and M. castaneus polymorphic residues (orange circles) and positively selected residues (open circles, black circles for sites with [P] > 0.95) are indicated at the top of the alignment. Conserved residues are indicated at the bottom of the alignment, as either identical (asterisks) or similar (dots).

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