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Figure 5 | BMC Evolutionary Biology

Figure 5

From: Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

Figure 5

Proliferative response of B and T cells to BALB/c and CAST/Ei IL4. (A) Shown are plots depicting the proliferative response of B cells from BALB/c (left panel) and CAST/Ei (right panel) stimulated with 50 ng/ml of LPS in the presence of graded concentrations of BALB/c (open) or CAST/Ei (closed) IL4. (B) Shown is a plot depicting the proliferative response of T cells from BALB/c (square) and CAST/Ei (triangle) cultured in the presence of graded concentrations of BALB/c (open symbols) or CAST/Ei (closed symbols) IL4. Proliferation was measured as the rate of AlamarBlue reduction. Data are the mean of duplicate measurements and are representative of 3 independent experiments with similar results.

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