Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 1 Summary Statistics of PAML analyses

From: Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

NSsites Model comparison 2 lnλ (df) p-value %codons dN/dS >1 average dN/dS
M7 vs M8, eutherian mammals- 28 taxa (including elephant, carnivores, rabbit, rodents, primates) 20.84 (2) <10 -4 15.2 1.87
M7 vs M8, eutherian mammals excluding Lagomorphs & Rodentia (21 mammals) 20.61 (2) <10 -4 16.7 2.14
M7 vs M8, Lagomorphs & Rodentia alone (7 taxa)* 19.56 (2) <10 -4 5.6 6.34
M7 vs M8, primates alone (16 taxa incl. 2 prosimians) 0.737 (2) >0.5 na na
M7 vs M8, eutherian mammals excluding primates (23 taxa) 17.28 (2) <0.0002 18.5 1.75
M7 vs M8, Laurasiatheria alone (15 taxa) 13.15 (2) <0.002 16.3 2.02
  1. All analyses were done using the Fcodon model. Results are qualitatively identical using the F3 × 4 model of codon substitution.
  2. lnλ = log likelihood difference between the two models
  3. df = degrees of freedom
  4. *Multiple topologies for rodent phylogenies were tested due to poor phylogenetic resolution in this lineage - the conclusion of positive selection is not dependent on the use of a particular topology; the values reported are those found when used with a phylogeny consistent with the consensus view of rodent evolution.