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Table 2 C2 domain similarity compared to corresponding C2 domains from human dysferlin (Type 1) and otoferlin (Type 2).

From: Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins

Type

Ferlin

C2A

C2B

C2C

C2D

C2DE

C2E

C2F

1

FER1L1_Tadh

37.1

71.4

65

61

72

79

76.9

1

FER1L3_Tadh

47

69.4

62.7

59.1

49.3

80

51.4

1

FER1L1_Nvec

 

44.5

68.1

55.6

 

78

76.2

1

FER1L1_Ccap

  

68.7

60

75

75

80.8

1

FER1L1_Lgig

 

70.4

68.1

67

52.1

76

76.9

1

FER1L1_Sman

 

66.3

55.8

59.6

 

73

79.2

1

FER_Cele

  

34.6

41.8

 

66

49.3

1

FER1L1_Bmal

  

30.6

54.3

49.5

65.3

60.6

2

FER1L2_Tadh

 

73.3

64.9

66.1

 

87

72.5

2

FER1L2_Nvec

78.1

72.7

85.7

69.7

53.4

89

78.6

2

FER1L2_Ccap

  

56.4

64.2

 

71

78.6

2

FER1L2_Lgig

 

85.9

89.3

77.1

 

92

90.1

2

FER1L2_Sman

 

26.8

57.5

39.3

 

75

70.2

2

FER1L1_Phum

 

87.9

87.5

76.1

 

89

90.8

2

Misfire_Dmel

 

52.3

37.9

40

 

66

 
  1. Key: The C2DE domain from FER1L2_Nvec was compared to dysferlin C2DE since otoferlin does not contain this corresponding C2 domain. Blank spaces indicate C2 domains not detected by SMART.