Figure 6

The correlations between EBs and Ka when gene compactness or essentiality is controlled. (A) Essentiality was estimated by mouse KO phenotypes (Methods). A total of 1,868 essential genes and 2,124 non-essential genes were identified. In each group, ten different genes were grouped together into a bin, and a total of 186 bins of essential genes and 212 bins of non-essential genes were made. Kendall's rank correlation tests were used to see the correlations between EBs and Ka in each group. (B) The information about gene structure was retrieved from UCSC (Methods). A total of 9,025 genes with all the information needed for this analysis, including intron number, EB, EA, and Ka were selected. Then all the genes were grouped into nine different groups, with each group containing a similar number of genes (717-1112). For each group, the correlation tests between EBs and Ka were performed using Kendall's rank correlation test. The tau values and p-values for the correlation tests in each group are shown as a box graph (top) and table (bottom), respectively.