Figure 2

PDE4 gene phylogeny. Maximum likelihood and Bayesian phylogenetic trees constructed using amino acid sequences from UCR-1, UCR-2 and the catalytic domain from each PDE4 gene isoform of each taxa. Branch support following 1000 replicates is shown in bootstrap values at each divergence point. The trees were rooted with Ciona intestinalis. Maximum likelihood bootstrap values (top) and Bayesian posterior probabilities (below) are indicated at each node. Taxa are represented by the first letter of the genus name and first three letters of species name. NS = not supported. The number of splice variants for each gene isoform are indicated in parenthesis as; (long, short, super-short, and truncated super-short forms), respectively. Each PDE4 gene isoform clade is indicated by brackets.