Lineage specific expansions and contractions in number of NRPS genes per genome. Inferred number of NRPS encoding genes at ancestral nodes mapped onto the ultrametric tree of fungi. Timescale in millions of years is shown along bottom. Branches with significant expansions (blue) or contractions (red) are shown with associated p-values above branches. The largest contraction in number of NRPSs occurs in N. crassa while the largest expansion occurs in the ancestor of euascomycetes. A highly significant expansion also occurs in F. graminearum and significant expansions occur in several other euascomycete taxa (e.g., M. oryzae and on the branch leading to the Aspergillus species).