Conserved domain architectures for mono-bimodular NRPS subfamilies. The majority of mono-bimodular subfamilies have an A-T domain structure followed by various C-terminal domains. Only ChNPS11/ETP module 1 and ETP module 2 show complete A-T-C modules. The ChNPS12/ETP module 2 subfamily also contains representatives consisting of a single A domain. Domains: A = adenylation, T = thiolation, C = condensation, R = thioester reductase, D = ADH short chain dehydrogenase, PKS = polyketide synthase module, FeR = ferric reductase, FSH/SH = serine hydrolase, RH = polynucleotidyl transferase, Ribonuclease H, LPS = LPS-induced tumor necrosis alpha factor.