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Table 3 Panther over-represented categories among genes showing correlation with helminth diversity

From: The landscape of human genes involved in the immune response to parasitic worms

PANTHER category PANTHER description Number of genes p valuea Contributing genes
Pathway Integrin signalling pathway 26 0.0067 ITGAV, COL4A1, ITGA8, FLNB, ITGA9, ITGB8, ITGAM, ITGBL1, COL4A2, COL1A2, DOCK2, PTK2B, ITGAX, FYN, MAPK13, LAMA2, ITGAL, LIMS1, COL24A1, ELMO1, COL15A1, DOCK1, GRB2, ITGB7, MAPK14, COL9A3
  Alpha adrenergic receptor signaling pathway 8 0.0138 PLCB1, ADRA1A, ITPR1, GNAQ, SNAP25, PLCE1, VAMP3, ITPR2
  Inflammation mediated by chemokine and cytokine signaling pathway 31 0.0206 SOCS6, PLCH2, PLCB1, GRB2, GNG10, ITPR1, CXCR6, MYH14, ITGA9, MYO3B, PLA2G4B, GNAQ, CAMK2A, PLCL1, CAMK2 D, ITGAM, CCR9, COL1A2, ITGB7, PAK7, VAV2, PLCD3, ADCY2, PTK2B, PLCE1, RELA, ITPR2, CCL20, PLA2G4A, ITGAL, COL23A1
  Ionotropic glutamate receptor pathway 11 0.0263 SLC17A8, GRIK2, GRIA1, CACNG5, GRIN3A, SHANK2, CAMK2A, SNAP25, CAMK2 D, VAMP3, CACNG8
  Thyrotropin-releasing hormone receptor signaling pathway 11 0.0303 PLCH2, PLCB1, CGA, CACNB2, GNG10, GNAQ, PLCD3, CHGA, PLCE1, VAMP3, SNAP25
Biological process Signal transduction 270 4.05 × 10-17 n.r.
  Cell adhesion 73 7.18 × 10-11 n.r.
  Cell communication 113 9.11 × 10-10 n.r.
  Cell structure and motility 103 1.35 × 10-8 n.r.
  Neuronal activities 63 2.25 × 10-8 n.r.
  Developmental processes 163 2.87 × 10-8 n.r.
  Ion transport 64 8.48 × 10-7 n.r.
  Cation transport 54 1.61 × 10-6 n.r.
Molecular function Ion channel 44 4.06 × 10-7 n.r.
  Receptor 117 2.79 × 10-6 n.r.
  Hydrolase 66 1.92 × 10-5 n.r.
  G-protein modulator 45 2.84 × 10-5 n.r.
  Cell adhesion molecule 42 3.92 × 10-5 n.r.
  Signaling molecule 68 6.44 × 10-5 n.r.
  Membrane-bound signaling molecule 20 8.95 × 10-4 n.r.
  1. a p values are Bonferroni corrected
  2. n.r.: not reported