Figure 1

The PARP gene family forms six clades. A. Graphical representation of the maximum-likelihood (ML) phylogenetic tree of all identified eukaryotic PARPs indicating the relationships between the six clades as defined in the text. The full tree can be found in Additional file 4. The tree was based on an alignment of the PARP catalytic domains (Additional file 3). B. Graphical representation of the ML phylogenetic tree of Clade 1 PARPs indicating the relationships between nine subclades as defined in the text. C. Graphical representation of the ML phylogenetic tree of Clade 2 indicating the relationships between the two subclades as defined in the text. D. Graphical representation of the ML phylogenetic tree of Clade 3 PARPs indicating the relationships between the six subclades as defined in the text. E. Graphical representation of the ML phylogenetic tree of Clade 5 PARPs indicting the relationship between the two subclades as defined in the text. F. Graphical representation of the maximum-likelihood (ML) phylogenetic tree of Clade 6 PARPs indicating the relationships between the six subclades as defined in the text. Numbers in the clades or subclades indicate the number of proteins in each. Colors and letters indicate the eukaryotic supergroup or groups represented. A, Amoebozoa; O, Opithokonts; E, Excavata; P, Plantae; C, Chromalveolates. Purple, Amoebozoa; red, Opithokonts; orange, Excavata; green, Plantae; blue, chromalveolates. Branch support values are indicated at the nodes as computed in PhyML using an aLRT non-parametric Shimodaira-Hasegawa-like (SH) procedure and a midpoint rooting method. Triangle and branch colors indicate either the presence of the HYE (red) or variant (blue) catalytic triad in each group. Branch lengths do not indicate genetic distance.