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Table 2 Accelerated evolution of trappin multigenes.

From: Evolution of trappin genes in mammals

Line

Region

Armadillo

Cow

Pig

Elephant

Hyrax

Guinea pig

A1

5' flanking region

0.059 ± 0.009

0.115 ± 0.042

0.090 ± 0.008

0.108 ± 0.013

0.010 ± 0.003

0.01 ± 0.003

0.610 ± 0.051

0.850 ± 0.108

0.935 ± 0.039

1.574 ± 0.136

ND

A2

exon 1 (signal peptide)

0.010 ± 0.007

0.016 ± 0.236

0.066 ± 0.026

0.156 ± 1.227

0.078 ± 0.026**

0.286 ± 47.78

0.433 ± 0.099

0.682 ± 0.744

0.708 ± 0.158

2.728 ± 3.455

0.318 ± 0.063

0.588 ± 0.242

A3

intron 1

0.060 ± 0.006

0.163 ± 0.033

0.101 ± 0.009

0.058 ± 0.011

0.017 ± 0.004

0.017 ± 0.004

0.914 ± 0.073

1.326 ± 0.188

0.807 ± 0.046

1.132 ± 0.098

0.397 ± 0.026

0.534 ± 0.034

A4

exon 2 (TGS and WAP)

0.235 ± 0.025**

0.442 ± 0.110

0.167 ± 0.019**

0.299 ± 0.067

0.220 ± 0.022**

0.307 ± 0.040

0.430 ± 0.049

0.577 ± 0.095

0.576 ± 0.066

0.953 ± 0.267

ND***

A5

intron 2

0.045 ± 0.010

0.131 ± 0.280

0.057 ± 0.011

0.094 ± 0.036

0.044 ± 0.008**

0.046 ± 0.008

0.750 ± 0.089

1.083 ± 0.240

0.645 ± 0.081

0.845 ± 0.135

0.403 ± 0.040

0.495 ± 0.066

A6

exon 3 (non coding)

0.077 ± 0.014

0.142 ± 0.095

0.026 ± 0.009

0.032 ± 0.018

0.004 ± 0.004

0.004 ± 0.005

0.420 ± 0.069

0.568 ± 0.161

0.662 ± 0.105

0.990 ± 0.238

0.417 ± 0.052

0.579 ± 0.113

A7

3' flanking region

0.026 ± 0.006

0.045 ± 0.022

0.038 ± 0.006

0.052 ± 0.014

0.016 ± 0.003

0.016 ± 0.003

0.615 ± 0.049

0.815 ± 0.100

0.862 ± 0.034

1.223 ± 0.075

0.363 ± 0.035

0.419 ± 0.050

B1

entire gene except coding region

0.054 ± 0.004

0.079 ± 0.008

0.053 ± 0.003

0.070 ± 0.006

0.019 ± 0.002

0.019 ± 0.002

0.716 ± 0.041

1.092 ± 0.082

1.540 ± 0.024

1.531 ± 0.054

0.376 ± 0.022

0.438 ± 0.032

C1

pre

0.012 ± 0.009

0.022 ± 297.0

0.064 ± 0.022

0.143 ± 1.791

0.071 ± 0.027**

0.097 ± 196000

0.271 ± 0.074

0.344 ± 0.130

0.591 ± 0.141

1.940 ± 5.811

0.318 ± 0.063

0.475 ± 0.671

C2

pre (non synonymous)

0.009 ± 0.009

0.043 ± 0.029

0.059 ± 0.037**

0.226 ± 0.079

0.489 ± 0.152

0.287 ± 0.060

C3

pre (synonymous)

0.020 ± 0.020

0.120 ± 0.058

0.068 ± 0.053**

0.384 ± 0.196

0.942 ± 0.530

0.405 ± 0.155

 

dn/ds

0.5

0.4

0.9

0.6

0.5

0.7

D1

TGS

0.118 ± 0.023*

0.213 ± 0.145

0.195 ± 0.031**

0.387 ± 0.229

0.353 ± 0.039**

0.638 ± 0.137

0.604 ± 0.101

0.803 ± 0.214

0.977 ± 0.168

2.166 ± 1.289

0.474 ± 0.038

0.814 ± 0.056

D2

TGS (non synonymous)

0.147 ± 0.036*

0.211 ± 0.046**

0.355 ± 0.056**

0.724 ± 0.165

1.097 ± 0.322

0.452 ± 0.049

D3

TGS (synonymous)

0.057 ± 0.027

0.153 ± 0.056

0.288 ± 0.068**

0.355 ± 0.126

0.726 ± 0.203

0.533 ± 0.086

 

dn/ds

2.6

1.4

1.2

2.0

1.5

0.8

E1

WAP

0.309 ± 0.040**

0.364 ± 2.671

0.145 ± 0.028**

0.325 ± 0.037

0.209 ± 0.038**

0.376 ± 0.084

0.337 ± 0.061

0.492 ± 0.171

0.439 ± 0.073

0.702 ± 0.284

0.601 ± 0.087

1.235 ± 1.552

E2

WAP (non synonymous)

0.326 ± 0.067**

0.163 ± 0.044**

0.248 ± 0.051**

0.310 ± 0.093

0.366 ± 0.096

0.609 ± 0.133

E3

WAP (synonymous)

0.315 ± 0.070**

0.091 ± 0.039

0.134 ± 0.060**

0.460 ± 0.152

0.632 ± 0.233

0.733 ± 0.249

 

dn/ds

1.0

1.8

1.9

0.7

0.6

0.8

  1. Average JC (upper) and TN (lower) distances of each region among the trappin multigenes for each species (A1--E3) and estimated times of gene duplication (F1--F2) are shown. For each species, the accelerated evolution of each region (A1--A7, C1--E3) was assessed by making comparisons against the average distances of non-coding regions (B2). The bold letters indicate the distances of regions which evolved faster than the non-coding regions of the same genes. * P < 0.05, ** P < 0.01. *** In guinea pig, there is only one trappin gene that has both the TGS and WAP domains. ND, no data; pre, signal peptide (pre-sequence).