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Table 1 Correlation of human protein-coding gene properties with phyletic age and expression breadth

From: Human functional genetic studies are biased against the medically most relevant primate-specific genes

Category

Property

Phyletic age

Expression breadth

  

R a

P

R a

P

 

Age

-

-

0.270

< 10-15***

Structural

     
 

Protein length (log)

0.340

< 10-15***

0.113

< 10-15***

 

Exon number

0.290

< 10-15***

0.185

< 10-15***

 

CpG+/TATA- promoter

0.217

< 10-15***

0.394

< 10-15***

 

Length 1st intron (log)

0.103

< 10-15***

0.063

6.0×10-14***

 

Length of 5' UTR (log)

0.029

0.0005***

0.127

< 10-15***

 

GC content of CDS

-0.110

< 10-15***

-0.120

< 10-15***

Functional

     
 

Molecular functions

-0.543

< 10-15***

-0.178

< 10-15***

 

Pathway class

-0.264

< 10-15***

-0.025

0.042 *

 

Expression level (log)

0.162

< 10-15***

0.611

< 10-15***

Evolutionary

     
 

Ka

-0.275

< 10-15***

-0.258

< 10-15***

 

Ks

-0.062

1.3 × 10-11***

-0.050

8.9 × 10-09***

 

Ka/Ks

-0.336

< 10-15***

-0.274

< 10-15***

  1. a Pearson's correlation coefficient. * P < 0.05;** P < 0.01;*** P < 0.001.