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Table 2 Influence of expression breadth, phyletic age and expression abundance on protein properties using generalized linear modela

From: Human functional genetic studies are biased against the medically most relevant primate-specific genes

Category

Property

P(phyletic age)

P(expression breadth)

P(expression abundance)

Structural

    
 

Protein length (log)

< 10-15***

4.7 × 10-13***

< 10-15***

 

Exon number

< 10-15***

< 10-15***

5.50 × 10-13***

 

CpG+/TATA- promoter

2.30 × 10-14***

< 10-15***

0.0405*

 

1st intron length (log)

0.0061**

0.0240 *

4.43 × 10-05***

 

Length 5' UTR (log)

0.00747**

< 10-15***

4.31 × 10-05***

 

GC of CDS

< 10-15***

< 10-15***

8.34 × 10-11***

Functional

    
 

Molecular function (GO)

< 10-15***

< 10-15***

0.0739

 

Pathway class (KEGG)

< 10-15***

7.17 × 10-6***

0.0121*

Evolutionary

    
 

Ka

< 10-15***

< 10-15***

0.180

 

Ks

7.84 × 10-5***

2.41 × 10-7***

0.428

 

Ka/Ks

< 10-15***

< 10-15***

0.000354***

MainFactors

    
 

Age

-

< 10-15***

0.348

 

EST breadth

< 10-15***

-

< 10-15***

 

Expression abundance

0.348

< 10-15***

-

  1. Numbers are the corresponding P-values, * P < 0.05;** P < 0.01;*** P < 0.001.
  2. a We used a form like 'property ~ phyletic age + expression breadth + expression abundance' in the generalized linear model analysis. This form will produce three p-values showing the influence of phyletic age, expression breadth and expression abundance on 'property' respectively; p-values less than certain threshold (0.05 for example) suggest significant contribution of some factors to the 'property'; multiple significant p-values suggest the corresponding factors contribute independently to the 'property'.
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BMC Ecology and Evolution

ISSN: 2730-7182

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