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Table 1 AMFE Comparison between non-conserved and conserved pre-miRNAs from human, mouse, and chicken genomes

From: Correlation between sequence conservation and structural thermodynamics of microRNA precursors from human, mouse, and chicken genomes

Species Conservation AMFE (kcal/mol) p 1 p 2
Human S n (132) 44.1 ± 14.1   
  S c 1 (60) 45.2 ± 9.98 5.4×10-1 *3.7×10-3
  S c 2 (66) 44.6 ± 7.06 7.8×10-1 *8.6×10-9
  S c 3 (33) 44.7 ± 6.36 7.5×10-1 *2.3×10-6
Mouse S n (108) 41.0 ± 9.79   
  S c 1 (63) 45.1 ± 7.83 *5.2×10-3 *4.5×10-2
  S c 2 (75) 45.0 ± 6.93 *2.4×10-3 *1.4×10-4
  S c 3 (39) 43.8 ± 5.89 5.6×10-2 *4.8×10-4
Chickena S n (21) 42.2 ± 14.7   
  S c 2 (40) 41.6 ± 5.59 8.7×10-1 *3.3×10-7
  S c 3 (19) 42.3 ± 5.05 9.8×10-1 *3.1×10-5
  1. The number of pre-miRNAs within each set is indicated in brackets behind set name. a S c 1 for chicken was excluded as it contained fewer than five pre-miRNAs. AMFE, the AMFE mean values (± SD). Pair-wise comparisons were performed between non-conserved (S n ) and conserved pre-miRNAs (S c 1, S c 2, and S c 3) from human, mouse, and chicken genomes. p1, P-value of two-sample two-sided t-test (without assuming equal variance) for AMFE means. p2, P-value of two-sample two-sided F-test for AMFE variances. * the P-value is significant at the 0.05 FDR level.