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Table 4 Ka/Ks substitution ratios in CCT8L genes evolution

From: Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

Foreground genes1 Background genes1 Foreground Ka/Ks2 LRT (p)3 Foreground branches4
All CCT8L1/2 Human CCT8, Human CCT7 0.29 205.06 (<0.001) 1 to 25
Human CCT8L1 Chimp CCT8L1, Human CCT8L2 0.58 0.88 1
Chimp CCT8L1 Human CCT8L1, Human CCT8L2 1.02 0.00 2
Human CCT8L2 Chimp CCT8L2, Human CCT8L1 0.48 1.2 4
Chimp CCT8L2 Human CCT8L1, Human CCT8L2 0.39 1.8 5
Human CCT8L2 Human CCT8L1, Rhesus CCT8L 0.42 4.02 (<0.05) 4+6
Human CCT8L1 Human CCT8L2, Rhesus CCT8L 0.29 5.72 (<0.05) 1+3
Mouse and Rat CCT8L Cow CCT8L, Human CCT8L2 0.38 31.14 (<0.001) 12+13+14
Mouse CCT8L Rat CCT8L, Human CCT8L2 0.64 1.21 12
Rat CCT8L Mouse CCT8L, Human CCT8L2 0.49 5.91 (<0.05) 13
Rhesus CCT8L Lemur CCT8L, Human CCT8L2 0.73 (0.55)5 1.91 (1.22)5 8
Lemur CCT8L Human CCT8L2, Mouse CCT8L 0.29 36.82 (<0.001) 10
Dog CCT8L Cow CCT8L, Human CCT8L2 0.31 12.07 (<0.001) 16
Cow CCT8L Dog CCT8L, Human CCT8L2 0.13 113.78 (<0.001) 17
Armadillo CCT8L Elephant CCT8L, Human CCT8L2 0.36 0.57 20
Elephant CCT8L Marsupial CCT8L, Human CCT8L2 0.29 14.96 (<0.001) 21
Marsupial CCT8L Elephant CCT8L, Human CCT8L2 0.31 62.63 (<0.001) 23+24
  1. 1See text for the definition and meaning of Foreground and Background species; 2Ka/Ks is the estimated ratio of non-synonymous and synonymous substitution rates; 3LRT, Likelihood Ratio Test results for estimated Ka/Ks vs. Ka/Ks = 1.0 (see Methods). Probabilities (p) not shown signify p > 0.05; 4Foreground-branch numbers correspond to the numbering in the schematic tree shown in Figure 3. 5Values in parenthesis were obtained after removing an unusually diverged region from rhesus CCT8L (see text).