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Table 4 Ka/Ks substitution ratios in CCT8L genes evolution

From: Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

Foreground genes1

Background genes1

Foreground Ka/Ks2

LRT (p)3

Foreground branches4

All CCT8L1/2

Human CCT8, Human CCT7

0.29

205.06

(<0.001)

1 to 25

Human CCT8L1

Chimp CCT8L1, Human CCT8L2

0.58

0.88

1

Chimp CCT8L1

Human CCT8L1, Human CCT8L2

1.02

0.00

2

Human CCT8L2

Chimp CCT8L2, Human CCT8L1

0.48

1.2

4

Chimp CCT8L2

Human CCT8L1, Human CCT8L2

0.39

1.8

5

Human CCT8L2

Human CCT8L1, Rhesus CCT8L

0.42

4.02

(<0.05)

4+6

Human CCT8L1

Human CCT8L2, Rhesus CCT8L

0.29

5.72

(<0.05)

1+3

Mouse and Rat CCT8L

Cow CCT8L, Human CCT8L2

0.38

31.14

(<0.001)

12+13+14

Mouse CCT8L

Rat CCT8L, Human CCT8L2

0.64

1.21

12

Rat CCT8L

Mouse CCT8L, Human CCT8L2

0.49

5.91

(<0.05)

13

Rhesus CCT8L

Lemur CCT8L, Human CCT8L2

0.73 (0.55)5

1.91 (1.22)5

8

Lemur CCT8L

Human CCT8L2, Mouse CCT8L

0.29

36.82

(<0.001)

10

Dog CCT8L

Cow CCT8L, Human CCT8L2

0.31

12.07

(<0.001)

16

Cow CCT8L

Dog CCT8L, Human CCT8L2

0.13

113.78

(<0.001)

17

Armadillo CCT8L

Elephant CCT8L, Human CCT8L2

0.36

0.57

20

Elephant CCT8L

Marsupial CCT8L, Human CCT8L2

0.29

14.96

(<0.001)

21

Marsupial CCT8L

Elephant CCT8L, Human CCT8L2

0.31

62.63

(<0.001)

23+24

  1. 1See text for the definition and meaning of Foreground and Background species; 2Ka/Ks is the estimated ratio of non-synonymous and synonymous substitution rates; 3LRT, Likelihood Ratio Test results for estimated Ka/Ks vs. Ka/Ks = 1.0 (see Methods). Probabilities (p) not shown signify p > 0.05; 4Foreground-branch numbers correspond to the numbering in the schematic tree shown in Figure 3. 5Values in parenthesis were obtained after removing an unusually diverged region from rhesus CCT8L (see text).