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Table 6 Conservation of potential substrate-binding residue positions1

From: Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

Family I 2 i+12 i+42 Description
CCT1 K Y DE Lys/Tyr/Acidic
CCT2 Q L A (GQ)3 Gln/Leu/Ala
CCT3 H Y KR His/Tyr/Basic
CCT4 H F K His/Phe/Lys
CCT5 H L Q His/Leu/Gln
CCT6A D A K Asp/Ala/Lys
CCT6B DE AILMSV K (R) Acidic/Medium-Small/Lys
CCT7 Q Y D (Y) Gln/Tyr/Asp
CCT8 H Y K His/Tyr/Lys
CCT8L DILPT HLQR KNRY Variable/Variable/Polar-Basic
MKKS Q (H) FY (H) DEMQST Gln/Aromatic/Medium-Small
BBS10 Y (AFQS) CLY (W) LMQV Tyr/Variable/Variable
BBS12 E (KLQ) KR (HQ) HNR (ASD) Glu/Basic/Polar-Basic
Fab1_TCP4 D (EN) I (LMV) Q Asp/Ile/Gln
  1. 1 Conservation evaluated among sequences in vertebrate genomes. 2 Potential substrate binding positions, corresponding to yeast CCT1 positions 308, 309 and 312 (i = 308) [37]. 3Rare substitutions are listed in parenthesis. 4Fab1_TCP domain of vertebrate PIKFYVE orthologs.