Divergence in cis-regulatory sequences surrounding the opsin gene arrays of African cichlid fishes

Table 4 Conserved microRNA target sites within the 3'-UTRs of each opsin in O. niloticus and M. zebra

Opsin	miRNA	Target	Conserved¹	Function and expression	Ref(s)
SWS1	miR-725	TGACTGAG	GA	Expressed in fins	[55]
SWS2B	miR-217	ATGCAGTA	GA	Alters PTEN exp.; found in eye	[75, 78]
SWS2A	miR-181a	AGAATGTA	DR	T-cell regulation; found in eye	[75, 79]
RH2B	miR-23b	TATGTGAA	TR	Ganglion apoptosis; found in eye	[77, 116]
RH2Aα/β	miR-96	TTGCCAAA	OL	Sensory organ specific; found in eye	[76, 117]
	miR-182a	TTGCCAAA	OL	Sensory organ specific; found in eye	[76, 117]
LWS	miR-728	TTTAGTAA	GA,TN,TR	Unknown; found in eye	[55]
	miR-722*	GCAAAAAA	TR	Unknown; found in eye	[55]

¹ Other fish species in which this target site is also found: GA = stickleback (G. aculeatus), DR = zebrafish (D. rerio), TR = fugu (T. rubripes), TN = pufferfish (T. nigroviridis); OL = medaka (O. latipes)
* This site present in O. niloticus only

ISSN: 2730-7182