Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae

Table 6 Summary of defined alignment borders

DMT	Jack DL, Yang NM, Saier MH, Jr. (2001)	Pfam architecture	Frequency of architecture	New TM structure
Cation efflux	N/A	4-LC-2	96%	4+2
EamA	N/A	5+5	44%	5+5
DUF803	N/A	(1)+4	80%	4+5
DUF914	N/A	7+0	88%	5+5
DUF1632	9-10 TM	5+(3)	80%	5+5
NST	10 TM	(2)+6	97%	5+5
TPT	6-9 TM	(EamA)+4	77%	0+5
UAA	10 TM	3-LC-1-LC-5	93%	5+5
UPF0546	N/A	2+0	96%	4+0
Zip	N/A	2-LC-1-LC-1-2	93%	3+5

This table lists for human DMT families from [additional file 2: supplementary table S2], the evidence provided by Jack DL, Yang NM, Saier MH, Jr. (2001), and the Pfam dominant architecture and prevalence, and the TM structure recommended using evidence type from [additional file 5: supplementary table S4]. The parentheses in the Pfam architecture column indicate TMs or unrelated domains not covered by the Pfam-A hit to the current DMT.

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