Skip to main content

Table 1 Parameters used in the model

From: The evolution of plasmid-carried antibiotic resistance

Parameter

Description

n F

Density of wild-type/plasmid-free cells ('F' in figures)

n C

Density of cells with resistance on the chromosome ('C' in figures)

n P

Density of cells infected with a resistance-carrying plasmid ('Plasmids' in figures)

n B

Density of cells infected with a non-coding plasmid ('B' in figures)

n CP

Density of cells with resistance both on the chromosome and on a plasmid ('CP' in figures)

n CB

Density of cells infected with a non-coding plasmid, and with resistance on the chromosome ('CB' in figures)

N

Total density of cells

N = n F +n C +n P +n B +n CP +n CB

A

Concentration of antibiotic

l

Rate of decay of antibiotic

θ

Treatment dosage of antibiotic

Ï„

Interval between antibiotic treatments

r

Intrinsic per-capita growth rate of cells

a

Extrinsic density-dependent death rate of cells

m

Death rate of non-resistant cells, due to antibiotic

c C

Cost of antibiotic resistance when gene carried on chromosome

c P

Cost of antibiotic resistance when gene carried on plasmid

x

Cost of plasmid carriage

β

Rate of horizontal transfer of plasmids

s

Rate of segregation