Figure 1
From: Evolution of ligand specificity in vertebrate corticosteroid receptors
Phylogram of the evolutionary relationship of corticosteroid receptors based on DNA sequence identity. In addition to the receptors examined in this study (mouse, Mus musculus; midshipman fish, Porichthys notatus; daffodil cichlid, Neolamprologous pulcher), we included GRs and MRs from another cichlid (Burton's cichlid, Astatotilapia burtoni); a cartilaginous fish, the little skate (Leucoraja erinacea); and rainbow trout (Oncorhynchus mykiss) which have all been used in similar transactivational studies [2, 12, 13, 25]. The Burton's cichlid GRs are named according to a revised nomenclature [29]. Also included are the general corticosteroid receptor of a hagfish (Myxine glutinosa) and lamprey (Petromyzon marinus) that are evolutionarily basal to the radiation of GRs and MRs. The superscripts 'A' and 'C' indicate sensitivity to aldosterone and cortisol at ≤ 10-7 M based on our results and previous studies. *Aldosterone sensitivities of Burton's cichlid GR1 and rainbow trout GR2 are somewhat unclear [2, 12, 13].