Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins

Ainali, Chrysanthi; Simon, Michelle; Freilich, Shiri; Espinosa, Octavio; Hazelwood, Lee; Tsoka, Sophia; Ouzounis, Christos A; Hancock, John M

doi:10.1186/1471-2148-11-142

BMC Ecology and Evolution

Table 3 GSIS genes with disease associations

From: Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins

Gene	OMIM Code	Disease
GCK	125851	MODY, type II,
	125853	Insulin resistance, susceptibility to,
	602485	Hyperinsulinemic hypoglycemia, familial, 3
	606176	Diabetes, permanent neonatal
FBa	229600	Fructose intolerance
FBc	611881	Glycogen storage disease XII
PGP2	261670	Glycogen storage disease X
PK	102900	Adenosine triphosphate, elevated, of erythrocytes
	266200	Pyruvate kinase deficiency
PDCa	308930	Leigh syndrome, X-linked
	312170	Pyruvate dehydrogenase deficiency
PDCb	312170	Pyruvate dehydrogenase deficiency
OGDC	203740	Alpha-ketoglutarate dehydrogenase deficiency
SCSa	245400	Lactic acidosis, fatal infantile
SDHa	115310	Paraganglioma, familial chromaffin, 4
	171300	Pheochromocytoma, modifier of
	606864	Paraganglioma and gastric stromal sarcoma
	612359	Cowden-like syndrome
SDHb	252011	Mitochondrial respiratory chain complex II deficiency
	256000	Leigh syndrome, due to Cox deficiency
FM	150800	Multiple cutaneous and uterine leiomyomata
	605839	Leiomyomatosis and renal cell cancer
	606812	Fumarase deficiency
MT-ND1	252010	Mitochondrial complex I deficiency
MT-ND2	256000	Leigh syndrome, due to Cox deficiency
UQCRQ	124000	Mitochondrial complex III deficiency
Cox6B1	220110	Mitochondrial complex IV deficiency
Cox2	220110	Mitochondrial complex IV deficiency
Cox1	220110	Mitochondrial complex IV deficiency
GUT2P	125853	Insulin resistance, susceptibility to
IDHcc	137800	Glioblastoma, susceptibility to
PC	266150	Pyruvate carboxylase deficiency
ETF-QO	231680	Glutaricaciduria, type IIC
SOD2c	105400	Amyotrophic lateral sclerosis, susceptibility to
SOD2 m	612634	Microvascular complications of diabetes, susceptibility to

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