The evolutionary history of the SAL1 gene family in eutherian mammals

Table 4 Parameter estimates and likelihood scores for branch- site models for 5 species

Species	Model	l ⁽¹⁾	Estimates of parameters ⁽²⁾	2Δl⁽³⁾	Positively selected sites (BEB)
Marmoset	Null	-5660.37202	ρ0 = 0.18, (ρ1 = 0.39), ω0 = 0.23, (ω1 = 1)	18.47 ***	Not allowed
	Alternative	-5651.1375	ρ0 = 0.30, ρ1 = 0.63, (ρ2 = 0.07), ω0 = 0.23, (ω1 = 1), ω2 = 60.38		2 sites p > 95%: 159R, 161F
Dog	Null	-5660.55998	ρ0 = 0.25, (ρ1 = 0.52), ω0 = 0.24, (ω1 = 1)	6.78 **	Not allowed
	Alternative	-5657.16845	ρ0 = 0.28, ρ1 = 0.58, (ρ2 = s0.14), ω0 = 0.23, (ω1 = 1), ω2 = 11.15		2 sites p > 95%: 14H, 144Y
Guinea pig	Null	-5660.94116	ρ0 = 0.32, (ρ1 = 0.67), ω0 = 0.24, (ω1 = 1)	13.68 ***	Not allowed
	Alternative	-5654.10045	ρ0 = 0.27, ρ1 = 0.51, (ρ2 = 0.22), ω0 = 0.25, (ω1 = 1), ω2 = 3.94		3 sites p > 95%: 11S, 75C, 104V
Horse	Null	-5660.94121	ρ0 = 0.32, (ρ1 = 0.67), ω0 = 0.24, (ω1 = 1 )	27.22 ***	Not allowed
	Alternative	-5647.32999	ρ0 = 0.30, ρ1 = 0.61, (ρ2 = 0.09), ω0 = 0.24, (ω1 = 1), ω2 = 7.57		2 sites p > 99%: 75C, 119L; 1 site p > 95%: 144Y
Mouse	Null	-5658.60187	ρ0 = 0.24, (ρ1 = 0.55), ω0 = 0.19, (ω1 = 1 )	10.75 **	Not allowed
	Alternative	-5653.22783	ρ0 = 0.25, ρ1 = 0.58, (ρ2 = 0.17), ω0 = 0.19, (ω1 = 1), ω2 = 3.25		1 site p > 95%: 162Q

⁽¹⁾ Log- likelihood values.
⁽²⁾ ρ0, ρ1, and ρ2 are the proportions of codons subject to purifying selection, neutral evolution, and positive selection, respectively. ω0, ω1 and ω2 represented dN/dS for each class (purifying, neutral and positive selection, respectively).
⁽³⁾ ** significant at p < 0.01
*** significant at p < 0.001.
⁽⁴⁾ Underlined: amino acids involved in androstenol and androstenone binding.
Site numbers and amino acids refer to the pig SAL1 reference sequence PDB: 1GM6, except for the amino acid in bold, which is not part of the structure but comes from the dog genome sequence XP_855342.1.

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