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Table 2 Number of genes in each functional class with evidences of adaptive selection

From: Genetic adaptation of the antibacterial human innate immunity network

Functional Class

 

Africans

Europeans

 

N

Positive Selection

Balancing Selection

Positive Selection

Balancing Selection

Receptors

19

TLR2

LY96

LY64a, TLR9, TLR10a

CD14, LY96, TLR6

Adaptors

10

-

-

IRAK4 a

-

Modulators

6

SOCS2a, TOLLIP

-

-

-

Acute Phase

20

-

LTA, IL18RAP, IL1F5, IL1F7

IL18BP a

IL1F5, IL1A, IL1F10, IL18RAP, IL1F7

Cellular Immunity

10

-

-

-

-

Antiinf. Cytokines

10

-

-

TGFB2

-

Neutrophil

9

IL17B a

-

-

-

Chemokines

14

IL8 a

-

CCR4

-

Extracellular

6

-

-

ADAM33

-

Complement

8

-

CFH, C5, C3

-

C3

Effector

15

MPO, NGFR

NTRK1

MPO

ITGA8

Non classified

5

CTNNB1

-

TNFRSF18

-

  1. N, number of genes in each functional category.
  2. a Genes with evidences of positive selection showing an excess of derived alleles at high frequencies (Fay and Wu's H test).
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BMC Ecology and Evolution

ISSN: 2730-7182

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