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Figure 2 | BMC Evolutionary Biology

Figure 2

From: An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea

Figure 2

Multiple sequence alignment of representative taxa across the aSelB/aSelBL tree. Red boxes show the location of the GTP binding loops (G1-5). Green boxes show the location of 16S rRNA interaction sites in EF-Tu [28]. Residues in the core of the aminoacyl-binding pocket of aSelB are boxed in orange [27]. Symbols immediately beneath EF-Tu show sites that make contact with aminoacyl group (open squares), the acceptor stem (grey circles) and the T stem (filled squares) in the structure of tRNACys-EF-Tu [26]. The colored ruler shows the domains (red: GTPase, blue: domain II, green: domain III). The C terminal extension of aSelB is not shown. Symbols beneath the alignment show secondary structure based on aSelBL (PDB ID 2ELF). '>' is sheet and ')' is helix. Asterisked taxa names are those with a crystal structure (Figure 3).

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