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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Evolutionary view of acyl-CoA diacylglycerol acyltransferase (DGAT), a key enzyme in neutral lipid biosynthesis

Figure 4

Predicted transmembrane domain for Mouse (Mmu) DGAT1, DGAT2, ACAT1, ACAT2, MGAT1, and AWAT1 sequences. See Additional File 1 for sources. The TMHMM web tools of the Center for Biological Sequence Analysis, Technical University of Denmark TMHMM Server plots the probability of the ALDH sequence forming a transmembrane helix (0-1.0 on the y-axis) (shown in red for the relevant amino acid sequences) http://www.cbs.dtu.dk/services/TMHMM/. Eight predicted transmembrane helices are identified for each of the DGAT1, ACAT1 and ACAT2 sequences; in contrast, only one major transmembrane helix (or helices) was observed for DGAT2, MGAT1, MGAT2, AWAT1 and AWAT2 sequences; regions of all sequences predicted to be located inside or outside the membrane are shown in blue and pink, respectively. The Pfam:Mboat is represented by a dotted line to DGAT1, ACAT1 and ACAT2.

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