Figure 2

Folding scores for near-native sequences threaded through the conformation of the SAP protein are shown. The score distribution is shown as a landscape, with the percentage of the negative native score (i.e -S _gap ^native, see eq. 15) on the Z axis and coordinates in high-dimensional sequence space projected onto the X and Y axes via Sammon mapping. Smaller scores denote more stable sequences (in blue), with larger scores being less stable (becoming progressively more red). The native sequence is marked by a black dot. A) The score distribution for the informational scoring function. B) The score distribution for the physics-based scoring function.