TY - JOUR AU - O'Neill, L. A. AU - Bryant, C. E. AU - Doyle, S. L. PY - 2009 DA - 2009// TI - Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer JO - Pharmacol Rev VL - 61 UR - https://doi.org/10.1124/pr.109.001073 DO - 10.1124/pr.109.001073 ID - O'Neill2009 ER - TY - JOUR AU - Rakoff-Nahoum, S. AU - Medzhitov, R. PY - 2009 DA - 2009// TI - Toll-like receptors and cancer JO - Nat Rev Cancer VL - 9 UR - https://doi.org/10.1038/nrc2541 DO - 10.1038/nrc2541 ID - Rakoff-Nahoum2009 ER - TY - JOUR AU - Barton, G. M. AU - Kagan, J. C. PY - 2009 DA - 2009// TI - A cell biological view of Toll-like receptor function: regulation through compartmentalization JO - Nat Rev Immunol VL - 9 UR - https://doi.org/10.1038/nri2587 DO - 10.1038/nri2587 ID - Barton2009 ER - TY - JOUR AU - Akira, S. AU - Uematsu, S. AU - Takeuchi, O. PY - 2006 DA - 2006// TI - Pathogen recognition and innate immunity JO - Cell VL - 124 UR - https://doi.org/10.1016/j.cell.2006.02.015 DO - 10.1016/j.cell.2006.02.015 ID - Akira2006 ER - TY - JOUR AU - Takeuchi, O. AU - Akira, S. PY - 2010 DA - 2010// TI - Pattern recognition receptors and inflammation JO - Cell VL - 140 UR - https://doi.org/10.1016/j.cell.2010.01.022 DO - 10.1016/j.cell.2010.01.022 ID - Takeuchi2010 ER - TY - JOUR AU - Roach, J. C. AU - Glusman, G. AU - Rowen, L. AU - Kaur, A. AU - Purcell, M. K. AU - Smith, K. D. AU - Hood, L. E. AU - Aderem, A. PY - 2005 DA - 2005// TI - The evolution of vertebrate Toll-like receptors JO - Proc Natl Acad Sci USA VL - 102 UR - https://doi.org/10.1073/pnas.0502272102 DO - 10.1073/pnas.0502272102 ID - Roach2005 ER - TY - JOUR AU - Takeda, K. AU - Kaisho, T. AU - Akira, S. PY - 2003 DA - 2003// TI - Toll-like receptors JO - Annu Rev Immunol VL - 21 UR - https://doi.org/10.1146/annurev.immunol.21.120601.141126 DO - 10.1146/annurev.immunol.21.120601.141126 ID - Takeda2003 ER - TY - CHAP AU - Carty, M. AU - Bowie, A. G. PY - 2010 DA - 2010// TI - Recent insights into the role of Toll-like receptors in viral infection BT - Clin Exp Immunol ID - Carty2010 ER - TY - JOUR AU - Chaturvedi, A. P. S. PY - 2009 DA - 2009// TI - How location governs toll-like receptor signaling JO - Traffic VL - 10 UR - https://doi.org/10.1111/j.1600-0854.2009.00899.x DO - 10.1111/j.1600-0854.2009.00899.x ID - Chaturvedi2009 ER - TY - JOUR AU - Barton, G. M. PY - 2007 DA - 2007// TI - Viral recognition by Toll-like receptors JO - Semin Immunol VL - 19 UR - https://doi.org/10.1016/j.smim.2007.01.003 DO - 10.1016/j.smim.2007.01.003 ID - Barton2007 ER - TY - JOUR AU - Bell, J. K. AU - Mullen, G. E. AU - Leifer, C. A. AU - Mazzoni, A. AU - Davies, D. R. AU - Segal, D. M. PY - 2003 DA - 2003// TI - Leucine-rich repeats and pathogen recognition in Toll-like receptors JO - Trends Immunol VL - 24 UR - https://doi.org/10.1016/S1471-4906(03)00242-4 DO - 10.1016/S1471-4906(03)00242-4 ID - Bell2003 ER - TY - JOUR AU - Beutler, B. AU - Jiang, Z. AU - Georgel, P. AU - Crozat, K. AU - Croker, B. AU - Rutschmann, S. AU - Du, X. AU - Hoebe, K. PY - 2006 DA - 2006// TI - Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large JO - Annu Rev Immunol VL - 24 UR - https://doi.org/10.1146/annurev.immunol.24.021605.090552 DO - 10.1146/annurev.immunol.24.021605.090552 ID - Beutler2006 ER - TY - JOUR AU - Medzhitov, R. AU - Janeway, C. A. PY - 1997 DA - 1997// TI - Innate immunity: the virtues of a nonclonal system of recognition JO - Cell VL - 91 UR - https://doi.org/10.1016/S0092-8674(00)80412-2 DO - 10.1016/S0092-8674(00)80412-2 ID - Medzhitov1997 ER - TY - CHAP AU - Bhattacharjee, R. N. AU - Akira, S. PY - 2005 DA - 2005// TI - Toll-Like Receptor Signaling: Emerging Opportunities in Human Diseases and Medicine BT - Current Immunology Reviews ID - Bhattacharjee2005 ER - TY - JOUR AU - Zhu, J. AU - Mohan, C. PY - 2010 DA - 2010// TI - Toll-like receptor signaling pathways--therapeutic opportunities JO - Mediators Inflamm VL - 2010 UR - https://doi.org/10.1155/2010/781235 DO - 10.1155/2010/781235 ID - Zhu2010 ER - TY - JOUR AU - Jin, M. S. AU - Kim, S. E. AU - Heo, J. Y. AU - Lee, M. E. AU - Kim, H. M. AU - Paik, S. G. AU - Lee, H. AU - Lee, J. O. PY - 2007 DA - 2007// TI - Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide JO - Cell VL - 130 UR - https://doi.org/10.1016/j.cell.2007.09.008 DO - 10.1016/j.cell.2007.09.008 ID - Jin2007 ER - TY - JOUR AU - Kim, H. M. AU - Park, B. S. AU - Kim, J. I. AU - Kim, S. E. AU - Lee, J. AU - Oh, S. C. AU - Enkhbayar, P. AU - Matsushima, N. AU - Lee, H. AU - Yoo, O. J. AU - Lee, J. O. PY - 2007 DA - 2007// TI - Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran JO - Cell VL - 130 UR - https://doi.org/10.1016/j.cell.2007.08.002 DO - 10.1016/j.cell.2007.08.002 ID - Kim2007 ER - TY - JOUR AU - Wei, T. AU - Gong, J. AU - Jamitzky, F. AU - Heckl, W. M. AU - Stark, R. W. AU - Rossle, S. C. PY - 2009 DA - 2009// TI - Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains JO - Protein Sci VL - 18 UR - https://doi.org/10.1002/pro.186 DO - 10.1002/pro.186 ID - Wei2009 ER - TY - JOUR AU - Letunic, I. AU - Doerks, T. AU - Bork, P. PY - 2009 DA - 2009// TI - SMART 6: recent updates and new developments JO - Nucleic Acids Res VL - 37 UR - https://doi.org/10.1093/nar/gkn808 DO - 10.1093/nar/gkn808 ID - Letunic2009 ER - TY - JOUR AU - Offord, V. AU - Coffey, T. J. AU - Werling, D. PY - 2010 DA - 2010// TI - LRRfinder: a web application for the identification of leucine-rich repeats and an integrative Toll-like receptor database JO - Dev Comp Immunol VL - 34 UR - https://doi.org/10.1016/j.dci.2010.05.004 DO - 10.1016/j.dci.2010.05.004 ID - Offord2010 ER - TY - JOUR AU - Choe, J. AU - Kelker, M. S. AU - Wilson, I. A. PY - 2005 DA - 2005// TI - Crystal structure of human toll-like receptor 3 (TLR3) ectodomain JO - Science VL - 309 UR - https://doi.org/10.1126/science.1115253 DO - 10.1126/science.1115253 ID - Choe2005 ER - TY - JOUR AU - Liu, L. AU - Botos, I. AU - Wang, Y. AU - Leonard, J. N. AU - Shiloach, J. AU - Segal, D. M. AU - Davies, D. R. PY - 2008 DA - 2008// TI - Structural basis of toll-like receptor 3 signaling with double-stranded RNA JO - Science VL - 320 UR - https://doi.org/10.1126/science.1155406 DO - 10.1126/science.1155406 ID - Liu2008 ER - TY - JOUR AU - Park, B. S. AU - Song, D. H. AU - Kim, H. M. AU - Choi, B. S. AU - Lee, H. AU - Lee, J. O. PY - 2009 DA - 2009// TI - The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex JO - Nature VL - 458 UR - https://doi.org/10.1038/nature07830 DO - 10.1038/nature07830 ID - Park2009 ER - TY - JOUR AU - Chang, Z. L. PY - 2010 DA - 2010// TI - Important aspects of Toll-like receptors, ligands and their signaling pathways JO - Inflamm Res VL - 59 UR - https://doi.org/10.1007/s00011-010-0208-2 DO - 10.1007/s00011-010-0208-2 ID - Chang2010 ER - TY - CHAP AU - Uematsu, S. AU - Akira, S. PY - 2008 DA - 2008// TI - Toll-Like receptors (TLRs) and their ligands BT - Handb Exp Pharmacol ID - Uematsu2008 ER - TY - JOUR AU - Guan, Y. AU - Ranoa, D. R. AU - Jiang, S. AU - Mutha, S. K. AU - Li, X. AU - Baudry, J. AU - Tapping, R. I. PY - 2010 DA - 2010// TI - Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling JO - J Immunol VL - 184 UR - https://doi.org/10.4049/jimmunol.0901888 DO - 10.4049/jimmunol.0901888 ID - Guan2010 ER - TY - JOUR AU - Hasan, U. AU - Chaffois, C. AU - Gaillard, C. AU - Saulnier, V. AU - Merck, E. AU - Tancredi, S. AU - Guiet, C. AU - Briere, F. AU - Vlach, J. AU - Lebecque, S. PY - 2005 DA - 2005// TI - Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88 JO - J Immunol VL - 174 UR - https://doi.org/10.4049/jimmunol.174.5.2942 DO - 10.4049/jimmunol.174.5.2942 ID - Hasan2005 ER - TY - JOUR AU - Yoneyama, M. AU - Fujita, T. PY - 2010 DA - 2010// TI - Recognition of viral nucleic acids in innate immunity JO - Rev Med Virol VL - 20 UR - https://doi.org/10.1002/rmv.633 DO - 10.1002/rmv.633 ID - Yoneyama2010 ER - TY - JOUR AU - Alexopoulou, L. AU - Holt, A. C. AU - Medzhitov, R. AU - Flavell, R. A. PY - 2001 DA - 2001// TI - Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 JO - Nature VL - 413 UR - https://doi.org/10.1038/35099560 DO - 10.1038/35099560 ID - Alexopoulou2001 ER - TY - JOUR AU - Takeuchi, O. AU - Akira, S. PY - 2007 DA - 2007// TI - Recognition of viruses by innate immunity JO - Immunol Rev VL - 220 UR - https://doi.org/10.1111/j.1600-065X.2007.00562.x DO - 10.1111/j.1600-065X.2007.00562.x ID - Takeuchi2007 ER - TY - JOUR AU - Janssens, S. AU - Beyaert, R. PY - 2003 DA - 2003// TI - Role of Toll-like receptors in pathogen recognition JO - Clin Microbiol Rev VL - 16 UR - https://doi.org/10.1128/CMR.16.4.637-646.2003 DO - 10.1128/CMR.16.4.637-646.2003 ID - Janssens2003 ER - TY - JOUR AU - Mukherjee, S. AU - Sarkar-Roy, N. AU - Wagener, D. K. AU - Majumder, P. P. PY - 2009 DA - 2009// TI - Signatures of natural selection are not uniform across genes of innate immune system, but purifying selection is the dominant signature JO - Proc Natl Acad Sci USA VL - 106 UR - https://doi.org/10.1073/pnas.0811357106 DO - 10.1073/pnas.0811357106 ID - Mukherjee2009 ER - TY - JOUR AU - Barreiro, L. B. AU - Ben-Ali, M. AU - Quach, H. AU - Laval, G. AU - Patin, E. AU - Pickrell, J. K. AU - Bouchier, C. AU - Tichit, M. AU - Neyrolles, O. AU - Gicquel, B. PY - 2009 DA - 2009// TI - Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense JO - PLoS Genet VL - 5 UR - https://doi.org/10.1371/journal.pgen.1000562 DO - 10.1371/journal.pgen.1000562 ID - Barreiro2009 ER - TY - JOUR AU - Ortiz, M. AU - Kaessmann, H. AU - Zhang, K. AU - Bashirova, A. AU - Carrington, M. AU - Quintana-Murci, L. AU - Telenti, A. PY - 2008 DA - 2008// TI - The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates JO - Genes Immun VL - 9 UR - https://doi.org/10.1038/gene.2008.40 DO - 10.1038/gene.2008.40 ID - Ortiz2008 ER - TY - JOUR AU - Nakajima, T. AU - Ohtani, H. AU - Satta, Y. AU - Uno, Y. AU - Akari, H. AU - Ishida, T. AU - Kimura, A. PY - 2008 DA - 2008// TI - Natural selection in the TLR-related genes in the course of primate evolution JO - Immunogenetics VL - 60 UR - https://doi.org/10.1007/s00251-008-0332-0 DO - 10.1007/s00251-008-0332-0 ID - Nakajima2008 ER - TY - JOUR AU - Huang, Y. AU - Temperley, N. D. AU - Ren, L. AU - Smith, J. AU - Li, N. AU - Burt, D. W. PY - 2011 DA - 2011// TI - Molecular evolution of the vertebrate TLR1 gene family - a complex history of gene duplication, gene conversion, positive selection and co-evolution JO - BMC Evol Biol VL - 11 UR - https://doi.org/10.1186/1471-2148-11-149 DO - 10.1186/1471-2148-11-149 ID - Huang2011 ER - TY - JOUR AU - Hamblin, M. T. AU - Thompson, E. E. AU - Di Rienzo, A. PY - 2002 DA - 2002// TI - Complex signatures of natural selection at the Duffy blood group locus JO - Am J Hum Genet VL - 70 UR - https://doi.org/10.1086/338628 DO - 10.1086/338628 ID - Hamblin2002 ER - TY - JOUR AU - Vallender, E. J. AU - Lahn, B. T. PY - 2004 DA - 2004// TI - Positive selection on the human genome JO - Hum Mol Genet VL - 13 UR - https://doi.org/10.1093/hmg/ddh253 DO - 10.1093/hmg/ddh253 ID - Vallender2004 ER - TY - CHAP AU - Alcaide, M. AU - Edwards, S. V. PY - 2011 DA - 2011// TI - Molecular evolution of the Toll-like receptor multigene family in birds BT - Mol Biol Evol ID - Alcaide2011 ER - TY - JOUR AU - Wlasiuk, G. AU - Nachman, M. W. PY - 2010 DA - 2010// TI - Adaptation and constraint at Toll-like receptors in primates JO - Mol Biol Evol VL - 27 UR - https://doi.org/10.1093/molbev/msq104 DO - 10.1093/molbev/msq104 ID - Wlasiuk2010 ER - TY - JOUR AU - Rassa, J. C. AU - Ross, S. R. PY - 2003 DA - 2003// TI - Viruses and Toll-like receptors JO - Microbes Infect VL - 5 UR - https://doi.org/10.1016/S1286-4579(03)00193-X DO - 10.1016/S1286-4579(03)00193-X ID - Rassa2003 ER - TY - JOUR AU - Jann, O. C. AU - Werling, D. AU - Chang, J. S. AU - Haig, D. AU - Glass, E. J. PY - 2008 DA - 2008// TI - Molecular evolution of bovine Toll-like receptor 2 suggests substitutions of functional relevance JO - BMC Evol Biol VL - 8 UR - https://doi.org/10.1186/1471-2148-8-288 DO - 10.1186/1471-2148-8-288 ID - Jann2008 ER - TY - CHAP AU - Morozumi, T. AU - Uenishi, H. PY - 2009 DA - 2009// TI - Polymorphism distribution and structural conservation in RNA-sensing Toll-like receptors 3, 7, and 8 in pigs BT - Biochim Biophys Acta ID - Morozumi2009 ER - TY - JOUR AU - Shimazu, R. AU - Akashi, S. AU - Ogata, H. AU - Nagai, Y. AU - Fukudome, K. AU - Miyake, K. AU - Kimoto, M. PY - 1999 DA - 1999// TI - MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4 JO - J Exp Med VL - 189 UR - https://doi.org/10.1084/jem.189.11.1777 DO - 10.1084/jem.189.11.1777 ID - Shimazu1999 ER - TY - JOUR AU - Kumar, H. AU - Kawai, T. AU - Akira, S. PY - 2009 DA - 2009// TI - Toll-like receptors and innate immunity JO - Biochem Biophys Res Commun VL - 388 UR - https://doi.org/10.1016/j.bbrc.2009.08.062 DO - 10.1016/j.bbrc.2009.08.062 ID - Kumar2009 ER - TY - JOUR AU - Werling, D. AU - Jann, O. C. AU - Offord, V. AU - Glass, E. J. AU - Coffey, T. J. PY - 2009 DA - 2009// TI - Variation matters: TLR structure and species-specific pathogen recognition JO - Trends Immunol VL - 30 UR - https://doi.org/10.1016/j.it.2008.12.001 DO - 10.1016/j.it.2008.12.001 ID - Werling2009 ER - TY - JOUR AU - Govindaraj, R. G. AU - Manavalan, B. AU - Basith, S. AU - Choi, S. PY - 2011 DA - 2011// TI - Comparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesis JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0025118 DO - 10.1371/journal.pone.0025118 ID - Govindaraj2011 ER - TY - JOUR AU - Manavalan, B. AU - Basith, S. AU - Choi, S. PY - 2011 DA - 2011// TI - Similar Structures but Different Roles - An Updated Perspective on TLR Structures JO - Front Physiol VL - 2 UR - https://doi.org/10.3389/fphys.2011.00041 DO - 10.3389/fphys.2011.00041 ID - Manavalan2011 ER - TY - JOUR AU - Du, X. AU - Poltorak, A. AU - Wei, Y. AU - Beutler, B. PY - 2000 DA - 2000// TI - Three novel mammalian toll-like receptors: gene structure, expression, and evolution JO - Eur Cytokine Netw VL - 11 ID - Du2000 ER - TY - JOUR AU - Downing, T. AU - Lloyd, A. T. AU - O'Farrelly, C. AU - Bradley, D. G. PY - 2010 DA - 2010// TI - The differential evolutionary dynamics of avian cytokine and TLR gene classes JO - J Immunol VL - 184 UR - https://doi.org/10.4049/jimmunol.0903092 DO - 10.4049/jimmunol.0903092 ID - Downing2010 ER - TY - JOUR AU - Chen, J. S. AU - Wang, T. Y. AU - Tzeng, T. D. AU - Wang, C. Y. AU - Wang, D. PY - 2008 DA - 2008// TI - Evidence for positive selection in the TLR9 gene of teleosts JO - Fish Shellfish Immunol VL - 24 UR - https://doi.org/10.1016/j.fsi.2007.11.005 DO - 10.1016/j.fsi.2007.11.005 ID - Chen2008 ER - TY - JOUR AU - Janeway, C. A. AU - Medzhitov, R. PY - 2002 DA - 2002// TI - Innate immune recognition JO - Annu Rev Immunol VL - 20 UR - https://doi.org/10.1146/annurev.immunol.20.083001.084359 DO - 10.1146/annurev.immunol.20.083001.084359 ID - Janeway2002 ER - TY - CHAP AU - Takaki, A. AU - Yamazaki, A. AU - Maekawa, T. AU - Shibata, H. AU - Hirayama, K. AU - Kimura, A. AU - Hirai, H. AU - Yasunami, M. PY - 2011 DA - 2011// TI - Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques BT - Immunogenetics ID - Takaki2011 ER - TY - JOUR AU - Tschirren, B. AU - Raberg, L. AU - Westerdahl, H. PY - 2011 DA - 2011// TI - Signatures of selection acting on the innate immunity gene Toll-like receptor 2 (TLR2) during the evolutionary history of rodents JO - J Evol Biol VL - 24 UR - https://doi.org/10.1111/j.1420-9101.2011.02254.x DO - 10.1111/j.1420-9101.2011.02254.x ID - Tschirren2011 ER - TY - JOUR AU - Cormican, P. AU - Lloyd, A. T. AU - Downing, T. AU - Connell, S. J. AU - Bradley, D. AU - O'Farrelly, C. PY - 2009 DA - 2009// TI - The avian Toll-Like receptor pathway--subtle differences amidst general conformity JO - Dev Comp Immunol VL - 33 UR - https://doi.org/10.1016/j.dci.2009.04.001 DO - 10.1016/j.dci.2009.04.001 ID - Cormican2009 ER - TY - JOUR AU - Beutler, B. AU - Rehli, M. PY - 2002 DA - 2002// TI - Evolution of the TIR, tolls and TLRs: functional inferences from computational biology JO - Curr Top Microbiol Immunol VL - 270 ID - Beutler2002 ER - TY - JOUR AU - Kobe, B. AU - Deisenhofer, J. PY - 1995 DA - 1995// TI - A structural basis of the interactions between leucine-rich repeats and protein ligands JO - Nature VL - 374 UR - https://doi.org/10.1038/374183a0 DO - 10.1038/374183a0 ID - Kobe1995 ER - TY - JOUR AU - Ewald, S. E. AU - Lee, B. L. AU - Lau, L. AU - Wickliffe, K. E. AU - Shi, G. P. AU - Chapman, H. A. AU - Barton, G. M. PY - 2008 DA - 2008// TI - The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor JO - Nature VL - 456 UR - https://doi.org/10.1038/nature07405 DO - 10.1038/nature07405 ID - Ewald2008 ER - TY - JOUR AU - Andersen-Nissen, E. AU - Smith, K. D. AU - Bonneau, R. AU - Strong, R. K. AU - Aderem, A. PY - 2007 DA - 2007// TI - A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin JO - J Exp Med VL - 204 UR - https://doi.org/10.1084/jem.20061400 DO - 10.1084/jem.20061400 ID - Andersen-Nissen2007 ER - TY - JOUR AU - Wlasiuk, G. AU - Khan, S. AU - Switzer, W. M. AU - Nachman, M. W. PY - 2009 DA - 2009// TI - A history of recurrent positive selection at the toll-like receptor 5 in primates JO - Mol Biol Evol VL - 26 UR - https://doi.org/10.1093/molbev/msp018 DO - 10.1093/molbev/msp018 ID - Wlasiuk2009 ER - TY - JOUR AU - Jebanathirajah, J. A. AU - Peri, S. AU - Pandey, A. PY - 2002 DA - 2002// TI - Toll and interleukin-1 receptor (TIR) domain-containing proteins in plants: a genomic perspective JO - Trends Plant Sci VL - 7 UR - https://doi.org/10.1016/S1360-1385(02)02309-9 DO - 10.1016/S1360-1385(02)02309-9 ID - Jebanathirajah2002 ER - TY - JOUR AU - Turner, J. D. PY - 2003 DA - 2003// TI - A bioinformatic approach to the identification of bacterial proteins interacting with Toll-interleukin 1 receptor-resistance (TIR) homology domains JO - FEMS Immunol Med Microbiol VL - 37 UR - https://doi.org/10.1016/S0928-8244(03)00095-6 DO - 10.1016/S0928-8244(03)00095-6 ID - Turner2003 ER - TY - JOUR AU - Xu, Y. AU - Tao, X. AU - Shen, B. AU - Horng, T. AU - Medzhitov, R. AU - Manley, J. L. AU - Tong, L. PY - 2000 DA - 2000// TI - Structural basis for signal transduction by the Toll/interleukin-1 receptor domains JO - Nature VL - 408 UR - https://doi.org/10.1038/35047056 DO - 10.1038/35047056 ID - Xu2000 ER - TY - JOUR AU - Slack, J. L. AU - Schooley, K. AU - Bonnert, T. P. AU - Mitcham, J. L. AU - Qwarnstrom, E. E. AU - Sims, J. E. AU - Dower, S. K. PY - 2000 DA - 2000// TI - Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.7.4670 DO - 10.1074/jbc.275.7.4670 ID - Slack2000 ER - TY - JOUR AU - Hawn, T. R. AU - Verbon, A. AU - Lettinga, K. D. AU - Zhao, L. P. AU - Li, S. S. AU - Laws, R. J. AU - Skerrett, S. J. AU - Beutler, B. AU - Schroeder, L. AU - Nachman, A. PY - 2003 DA - 2003// TI - A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease JO - J Exp Med VL - 198 UR - https://doi.org/10.1084/jem.20031220 DO - 10.1084/jem.20031220 ID - Hawn2003 ER - TY - JOUR AU - Olson, M. V. PY - 1999 DA - 1999// TI - When less is more: gene loss as an engine of evolutionary change JO - Am J Hum Genet VL - 64 UR - https://doi.org/10.1086/302219 DO - 10.1086/302219 ID - Olson1999 ER - TY - JOUR AU - Olson, M. V. AU - Varki, A. PY - 2003 DA - 2003// TI - Sequencing the chimpanzee genome: insights into human evolution and disease JO - Nat Rev Genet VL - 4 UR - https://doi.org/10.1038/nrg981 DO - 10.1038/nrg981 ID - Olson2003 ER - TY - JOUR AU - Choo, K. H. AU - Tan, T. W. AU - Ranganathan, S. PY - 2009 DA - 2009// TI - A comprehensive assessment of N-terminal signal peptides prediction methods JO - BMC Bioinformatics VL - 10 UR - https://doi.org/10.1186/1471-2105-10-S15-S2 DO - 10.1186/1471-2105-10-S15-S2 ID - Choo2009 ER - TY - JOUR AU - Botos, I. AU - Liu, L. AU - Wang, Y. AU - Segal, D. M. AU - Davies, D. R. PY - 2009 DA - 2009// TI - The toll-like receptor 3:dsRNA signaling complex JO - Biochim Biophys Acta VL - 1789 UR - https://doi.org/10.1016/j.bbagrm.2009.06.005 DO - 10.1016/j.bbagrm.2009.06.005 ID - Botos2009 ER - TY - JOUR AU - Brinkmann, M. M. AU - Spooner, E. AU - Hoebe, K. AU - Beutler, B. AU - Ploegh, H. L. AU - Kim, Y. M. PY - 2007 DA - 2007// TI - The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling JO - J Cell Biol VL - 177 UR - https://doi.org/10.1083/jcb.200612056 DO - 10.1083/jcb.200612056 ID - Brinkmann2007 ER - TY - JOUR AU - Nishiya, T. AU - Kajita, E. AU - Miwa, S. AU - Defranco, A. L. PY - 2005 DA - 2005// TI - TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M504951200 DO - 10.1074/jbc.M504951200 ID - Nishiya2005 ER - TY - JOUR AU - Cargill, E. J. AU - Womack, J. E. PY - 2007 DA - 2007// TI - Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9 JO - Genomics VL - 89 UR - https://doi.org/10.1016/j.ygeno.2007.02.008 DO - 10.1016/j.ygeno.2007.02.008 ID - Cargill2007 ER - TY - JOUR AU - Mikula, I. AU - Bhide, M. AU - Pastorekova, S. PY - 2010 DA - 2010// TI - Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection JO - Vet Immunol Immunopathol VL - 138 UR - https://doi.org/10.1016/j.vetimm.2010.06.015 DO - 10.1016/j.vetimm.2010.06.015 ID - Mikula2010 ER - TY - JOUR AU - Esteves, P. J. AU - Abrantes, J. AU - Carneiro, M. AU - Muller, A. AU - Thompson, G. AU - van der Loo, W. PY - 2008 DA - 2008// TI - Detection of positive selection in the major capsid protein VP60 of the rabbit haemorrhagic disease virus (RHDV) JO - Virus Res VL - 137 UR - https://doi.org/10.1016/j.virusres.2008.07.025 DO - 10.1016/j.virusres.2008.07.025 ID - Esteves2008 ER - TY - JOUR AU - Snoeck, J. AU - Fellay, J. AU - Bartha, I. AU - Douek, D. C. AU - Telenti, A. PY - 2011 DA - 2011// TI - Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints JO - Retrovirology VL - 8 UR - https://doi.org/10.1186/1742-4690-8-87 DO - 10.1186/1742-4690-8-87 ID - Snoeck2011 ER - TY - JOUR AU - Drake, J. W. PY - 1999 DA - 1999// TI - The distribution of rates of spontaneous mutation over viruses, prokaryotes, and eukaryotes JO - Ann N Y Acad Sci VL - 870 UR - https://doi.org/10.1111/j.1749-6632.1999.tb08870.x DO - 10.1111/j.1749-6632.1999.tb08870.x ID - Drake1999 ER - TY - JOUR AU - Pond, S. L. AU - Frost, S. D. PY - 2005 DA - 2005// TI - Datamonkey: rapid detection of selective pressure on individual sites of codon alignments JO - Bioinformatics VL - 21 UR - https://doi.org/10.1093/bioinformatics/bti320 DO - 10.1093/bioinformatics/bti320 ID - Pond2005 ER - TY - JOUR AU - Yang, Z. PY - 2007 DA - 2007// TI - PAML 4: phylogenetic analysis by maximum likelihood JO - Mol Biol Evol VL - 24 UR - https://doi.org/10.1093/molbev/msm088 DO - 10.1093/molbev/msm088 ID - Yang2007 ER - TY - JOUR AU - Yang, Z. AU - Nielsen, R. AU - Goldman, N. AU - Pedersen, A. M. PY - 2000 DA - 2000// TI - Codon-substitution models for heterogeneous selection pressure at amino acid sites JO - Genetics VL - 155 ID - Yang2000 ER - TY - CHAP AU - Tamura, K. AU - Peterson, D. AU - Peterson, N. AU - Stecher, G. AU - Nei, M. AU - Kumar, S. PY - 2011 DA - 2011// TI - MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods BT - Mol Biol Evol ID - Tamura2011 ER - TY - JOUR AU - Wang, Y. AU - Geer, L. Y. AU - Chappey, C. AU - Kans, J. A. AU - Bryant, S. H. PY - 2000 DA - 2000// TI - Cn3D: sequence and structure views for Entrez JO - Trends Biochem Sci VL - 25 UR - https://doi.org/10.1016/S0968-0004(00)01561-9 DO - 10.1016/S0968-0004(00)01561-9 ID - Wang2000 ER - TY - JOUR AU - Kang, J. Y. AU - Nan, X. AU - Jin, M. S. AU - Youn, S. J. AU - Ryu, Y. H. AU - Mah, S. AU - Han, S. H. AU - Lee, H. AU - Paik, S. G. AU - Lee, J. O. PY - 2009 DA - 2009// TI - Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer JO - Immunity VL - 31 UR - https://doi.org/10.1016/j.immuni.2009.09.018 DO - 10.1016/j.immuni.2009.09.018 ID - Kang2009 ER -