Table 3 Positively selected sites predicted to affect TLR function based on their location in the three-dimensional structures

TLR1

318

Close to sites involved in heterodimerization TLR1-TLR2 (315 and 320)

[16]

TLR2

302

LRR10 - involved in ligand binding

TLR3

79

LRR2 - dsRNA-TLR3 interaction site (LRR-NT to LRR3)

[22]

285

Adjacent to site of SNP (N284I) that confers partial or total loss of function

295

Adjacent to sites (294 and 296) involved in ligand binding

300

In the region involved in ligand binding

TLR4

301

In the region involved in ligand binding

[23]

317

In the region involved in ligand binding

363

In the region involved in ligand binding

441

459

Irregular LRR insertion before LRR15

[18]

TLR8

472

481

Irregular LRR insertion before LRR15 - Alanine residue mutation could affect TLR8 activation.

[18] and [47]

498

LRR15 - involved in ligand binding

[18]