Figure 8

Malarial and human PIK3/4III kinase domains. Alignment of kinase domains of PI3K and PI4KIII kinases from Homo sapiens (Hs), Plasmodium falciparum (Plfa) and P. vivax (Plvi). Plasmodium species names and residues implicated in the kinase ATP-binding pocket are highlighted in red. Domains are from the PI3K C-γ (PIK3CG) structure reported by Walker et al. [47].