Maximum likelihood tree of the biotin carboxylase (BC) domain. This tree is based on 284representative sequences and 384 conserved sites and was arbitrarily roosted on the bacterialACC-related sequences. Numbers at nodes indicate bootstrap values higher than 50. Trianglescorrespond to collapsed groups of eukaryotes and Proteobacteria. Colors on leaves represent theaffiliation of the sequences to their respective domain of life: archaea (red), bacteria (blue) andeukaryotes (green). Bars on the right report the functional assignment of the sequences; sequencesthat are not in front of any bar are assumed to bear an acyl-CoA carboxylase activity.