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Table 1 Structural attributes and significant sites of the bHLH domain

From: Accurate discrimination of bHLH domains in plants, animals, and fungi using biologically meaningful sites

Site

Structural

CS-F

CS-A

CS-P

DT

pah

pss

ms

cc

ec

all

1

DP

          

2

DP

√

*

  

S

  

SC

S

S

3

           

4

           

5

DP

√

      

SC

 

S

6

P

     

S

   

C

7

           

8

DP

*

  

√

      

9

DP

√

*

 

√

     

C

10

P

*

*

√

    

C

 

C

11

P

*

         

12

DP

*

*

√

  

SC

C

  

C

13

DP

√

 

√

 

SC

SC

  

S

C

14

           

15

P

  

*

     

C

C

16

B

√

√

√

       

17

P

*

*

        

18

           

19

   

*

√

      

20

B

*

*

*

   

C

 

C

C

21

           

22

           

23

B

√

√

√

 

C

C

C

  

C

24

  

*

        

25

           

26

 

*

 

√

       

27

B

√

√

√

     

C

C

28

B

√

 

√

       

50

DPB

√

√

 

√

SC

 

C

C

 

SC

51

  

√

*

     

C

C

52

           

53

B

√

*

√

  

C

   

C

54

B

√

√

√

 

C

   

C

C

55

       

S

   

56

    

√

    

S

S

57

 

*

*

√

      

C

58

   

√

       

59

           

60

 

√

*

*

       

61

B

√

√

√

      

C

62

           

63

           

64

B

√

√

√

       
  1. NOTE.–The molecular architechure of bHLH positions is compiled from previous work on crystalline structures of animal proteins. Structural attributes noted are DNA contact of the E-box (D), phosphate backbone contact (P), or buried site within the hydrophobic core of the dimerized helicies (B). Highly (√) and moderately (*) conserved sites are denoted for plant (CS-P), animal (CS-A), and fungal (CS-F) sequences. Sites integral in the decision tree analysis (DT) are also reported. Last, SWDA (S) and CVA (C) significant sites are shown within each factor score dataset (pah, pss, ms, cc, ec and all).