Giant viruses coexisted with the cellular ancestors and represent a distinct supergroup along with superkingdoms Archaea, Bacteria and Eukarya

Table 4 Statistical test for the enrichment of FSFs in taxonomic groups using hypergeometric distribution for sampled viruses and bacteria

Comparison	k	n	M	N	P-value	Comment
Sampled viruses
ABEV_ABE	229	304	557	1739	9.80E-67	Overrepresented
BEV_BE	33	304	291	1739	0.0012	Underrepresented
BV_B	1	304	163	1739	1.80E-13	Underrepresented
BEV_BE	33	304	291	1739	0.0012	Underrepresented
ABV_AB	2	304	36	1739	0.035	Underrepresented
AV_A	1	304	22	1739	0.079	Underrepresented
AEV_AE	7	304	31	1739	0.29	Overrepresented
EV_E	25	304	335	1739	5.50E-09	Underrepresented
Bacteria
ABEV_ABE	229	1312	557	1739	3.1E-111	Under-represented
BEV_EV	33	1312	25	1739	<0.0001	Over-represented
ABV_AV	2	1312	1	1739	<0.0001	Over-represented
ABE_AE	557	1312	31	1739	<0.0001	Over-represented
BE_E	297	1312	335	1739	9.9E-9	Over-represented
AB_A	36	1312	22	1739	<0.0001	Over-represented
BV_V	1	1312	6	1739	0.0044	Under-represented

Significantly over-represented comparisons are highlighted in boldface.
k, number of FSFs in viral taxonomic group; n, total number of FSFs in viral supergroup; M, number of FSFs cellular taxonomic group; N, total number of FSFs studied.

ISSN: 2730-7182