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Table 1 The phylogenetic distribution of CL biosynthesis and maturation enzymes of five eukaryotic supergroups

From: The evolution of cardiolipin biosynthesis and maturation pathways and its implications for the evolution of eukaryotes

    

CL biosynthesis

 

CL maturation

  

Organism

CLD

 

Step one

Step two

    

CLS_cap

CLS_pld

 

iPLA2–γ

iPLA2–β

ALCAT

TAZ

  

Homo sapiens

+

-

+

+

+

+

+

  

Mus musculus

+

-

+

+

+

+

+

 

Animalia

Xenopus laevis

+

-

+

+

+

+

+

  

Gallus gallus

+

-

+

+

+

+

+

  

Danio rerio

+

-

+

+

+

+

+

  

Drosophila melanogaster

+

-

+

-

+

-

+

Opisthokonta

 

Caenorhabditis elegans

+

-

+

+

+

+

+

  

Hydra magnipapillata

+

-

+

 

+

+

+ a

  

Strongylocentrotus purpuratus

+

-

+

+

+

+

+

  

Schistosoma mansoni

+

-

+

 

+

+

+

  

Ciona intestinalis

+

-

+

+

+

+

+

 

Choanoflagellete

Monosiga brevicollis

+

-

+

-

-

+

+

 

Fungi

 

Saccharomyces cerevisiae

+

-

+

-

-

+

+

  

Ascomycota

Schizosaccharomyces pombe

+

-

+

 

-

+

-

   

Aspergillus fumigatus

+

-

+

-

+

+

+

  

Basidiomycota

Ustilago maydis

+

-

+

-

-

+

+

   

Cryptococcus

neoformans

+

-

+

-

-

+

+

   

Antonospora locustae

-

-

-

-

-

-

-

   

Encephalitozoon cuniculi

-

-

-

-

-

-

-

  

Microsporidia

Enterocytozoon bieneusi

-

-

-

-

-

-

-

   

Encephalitozoon intestinalis

-

-

-

-

-

-

-

Amoebozoa

Mycetozoa

Dictyostelium discoideum

-

+

-

-

+

+

+

  

Dictyostelium purpureum

-

+

-

-

+

+

+

 

Entamoebida

Entamoeba histolytica

-

-

-

-

-

-

-

  

Entamoeba dispar

-

-

-

-

-

-

-

  

Entamoeba invadens

-

-

-

-

-

-

 

Archaeplastida

Planta

Arabidopsis thaliana

+

-

+

+

-

+

+

  

Oryza sativa

+

-

+

+

-

+

+

 

Chlorophyta

Chlamydomonas reinhardtii

+

-

+

+

-

-

+

  

Ostreococcus lucimarinus

+

-

 

+

-

-

+

  

Ostreococcus tauri

+

-

 

+

-

 

+

  

Micromonas sp.

+

-

+

+

-

+

+

 

Rhodophyta

Cyanidioschyzon merolae

+

-

+

+

-

-

+

  

Galdieria sulphuraria #

+ a

-

-

-

-

-

+ a

Chromalveolata

Alveolata

Ciliata

Tetrahymena thermophila

-

+

+

-

-

-

-

   

Paramecium tetraurelia

-

+

+

-

-

-

-

  

Perkinsida

Perkinsus marinus

-

+

-

+

-

-

-

   

Plasmodium knowlesi

-

+

-

+

-

-

-

   

Plasmodium vivax

-

+

-

+

-

-

-

   

Plasmodium faciparum

-

+

-

+

-

-

-

  

Apicomplexa

Plasmodium chabaudi

-

+

-

+

-

-

-

   

Plasmodium yoelli yoelii

-

+

-

+

-

-

-

   

Cryptosporidium parvum

-

+

-

-

-

-

-

   

Cryptosporidium hominis

-

+

-

-

-

-

-

   

Cryptosporidium muris

-

+

-

-

-

-

-

   

Toxoplasma gondii

-

+

-

+

-

-

-

   

Babesia bovis T2Bo

-

+

-

+

-

-

-

   

Theileria parva

-

+

-

+

-

-

-

   

Theileria annulata

-

+

-

+

-

-

-

   

Pythium ultimum

+

-

+

-

-

+

+

   

Phytophthora sojae

+

-

+

-

-

+

 
  

Oomycetes

Phytophthora ramorum

+

-

+

-

-

+

+

   

Phytophthora infestans

+

-

+

-

-

+

+

 

Stramenopiles

 

Saprolegnia parasitica

+

-

+

-

-

+

+

  

Blastocystis hominis *

-

-

-

-

-

+

+

  

Bacillariophyta

Thalassiosira

pseudonana

+

-

+

+

-

-

+

   

Phaeodactylum tricornutum

+ a

-

+

+

-

+

-

  

Phaeophyceae

Ectocarpus siliculosus

+

-

+

+

-

+

+

Excavata

Kinetoplastids

Leishmania braziliensis

-

+

+

-

-

+

-

  

Leishmania infantum

-

+

+

-

-

+

-

  

Leishmania major

-

+

+

-

-

+

-

  

Trypanosoma brucei

-

+

+

-

-

+

-

  

Trypanosoma cruzi

-

+

-

-

-

+

-

 

Heterolobosea

Naegleria gruberi

 

+

-

+

-

 

+

 

Parabasalia

Trichomonas vaginalis

-

-

-

-

-

-

-

 

Diplomonadida

Giardia lamblia

-

-

-

-

-

-

-

  1. + = presence; - = absence; a, homologs obtained by tblastn search rather than by blastp search as others; *, nr database rather than genome database was searched against for homologs; #, EST database rather than genome database was searched against for homologs