Figure 3

A roadmap of perforin gene evolution created by tracking the perforin gene locus through extant vertebrate genomes. Scaffolds from the last common ancestors of vertebrate lineages are shown as pink lines (not to scale), with a grey background. Genome scaffolds from representative extant species are drawn as a black lines (not to scale), with a white background. Predicted scaffolds (where direct evidence is not available) are shown as dotted lines. Genes are shown as arrowheads, with their gene symbols above. Syntenic genes are color coded; genes that are not conserved are white with no label. The direction of the arrowhead indicates the relative transcriptional orientation and the relevant genome coordinates indicated on the right.