Figure 3
From: Molecular evolution of the polyamine oxidase gene family in Metazoa
Molecular models of the active site region of SMO and PAO. Schematic representation of the active site region of mouse SMO (MmSMO), Drosophila melanogaster PAO (DmPAO) and Saccharomyces cerevisiae PAO (FMS1) in complex with the substrate Spm. MmSMO and DmPAO complexes with Spm have been obtained by molecular modelling ([11] and this work, respectively) while the structure of the FMS1-Spm has been determined experimentally [14]. For the sake of clarity, the FAD cofactor is coloured in purple, backbone atoms in orange and Spm carbon atoms in green.