Figure 4
From: Molecular evolution of the polyamine oxidase gene family in Metazoa
Three-dimensional view of SMOs and APAOs sequence conservation. Structure-based views of the amino acid sequence conservation in the active site regions of vertebrate SMOs and APAOs. Protein regions coloured in blue correspond to residues conserved in at least 90% of the amino acid sequences analysed. Top panel: Amino acid sequence conservation in the SMO family mapped onto the structural model of mouse SMO [11]. Middle panel: Amino acid sequence conservation in the APAO family mapped onto the structural model of mouse APAO [12]. Bottom panel: Amino acid sequence conservation in the vertebrate PAO family (SMO and APAO sequences combined) mapped onto the structural model of mouse SMO. The green ellipse indicates the location of the polar pocket made up SMOs by residues Glu216 and Ser218 (numbering of the mouse enzyme), which are substituted by aliphatic amino acids in APAOs. The figure was generated using Jalview [32].