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Table 2 Summary of relevant results: Genes putatively affected by positive selection. Loci showing gene-level iHS extreme empirical p-value after Bonferroni multiple comparison correction is considered taking into account the number of continental groups and the two methods applied

From: Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation

Sub-pathway

Gene

Continental Group

p-value

Corrected p-values

Precursor Biosynthesis

ALG12

MENA

3 × 10-10

4.2 × 10-9

  

EUR

1 × 10-10

1.4 × 10-9

  

EASIA

5 × 10-11

7.0 × 10-10

 

GANAB

SSAFR

4 × 10-7

5.6 × 10-6

CNX_CRT

EDEM3

OCE

1 × 10-10

1.4 × 10-9

 

GCS1

MENA

2 × 10-14

2.8 × 10-13

  

EUR

2 × 10-16

2.8 × 10-15

  

CSASIA

2 × 10-6

2.8 × 10-5

 

UGCGL2

SSAFR

4 × 10-5

5.6 × 10-4

Branching 1

FUT8

SSAFR

1 × 10-4

1.4 × 10-3

 

MAN1A1

AME

5 × 10-13

7.0 × 10-12

 

MAN1A2

SSAFR

8 × 10-4

1.12 × 10-2

 

MAN2A1

SSAFR

4 × 10-23

5.6 × 10-22

  

EASIA

3 × 10-10

4.2 × 10-9

 

MGAT2

EASIA

4 × 10-7

5.6 × 10-6

 

MGAT3

EASIA

1 × 10-14

1.4 × 10-13

Branching 2

MGAT5B

MENA

1 × 10-7

1.4 × 10-6

  

EUR

7 × 10-8

9.8 × 10-7

 

ST8SIA3

MENA

5 × 10-10

7.0 × 10-9

  

EUR

2 × 10-8

2.8 × 10-7

Substrates

DPM1

MENA

5 × 10-12

7.0 × 10-11

  

EUR

1 × 10-8

1.4 × 10-7

  

CSASIA

2 × 10-16

2.8 × 10-15

 

DOLPP1

CSASIA

2 × 10-5

2.8 × 10-4

 

DPM2

EUR

5 × 10-7

7.0 × 10-6

 

DPM3

EASIA

6 × 10-30

8.4 × 10-29

  1. Populations were grouped as following: SSAFR, MENA, EUR, CSASIA, EASIA, OCE and AME standing respectively for Sub-Saharan Africa, Middle East-North Africa, Europe, Central South Asia, East Asia, Oceania and America.