ΔD values for the extended DD model under different parameter conditions. Increase in values of p and q and decrease of a lead to higher ΔD values in the network, divergence symmetry s has very little effect. Default parameter conditions are p = 0.2, q = 0.7, s = 0.5, a = 0.2, each plot shows ΔD values when one of these parameters is varied while the others are kept at default values (for full parameter sweeps we refer to Figure S16). The gray line is the ΔD value of the yeast LC PIN. Boxes show the .25 and .75 percentile of 20 runs, the error bars show the extreme values and the black line is the mean of 20 runs.