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Figure 2 | BMC Evolutionary Biology

Figure 2

From: Characterisation of the potential function of SVA retrotransposons to modulate gene expression patterns

Figure 2

The primary sequence of SVAs has the potential to form G-quadruplex DNA. A – Potential G4 DNA formation was analysed in silico. The fold difference in the relative contribution of each element to their proportion in the whole human genome was calculated and is displayed. B - The percentage of sequence from each SVA subtype that could potentially form G4 DNA in the human genome according to Quadparser software is shown; it was further sub-divided into the following elements: CCCTCT hexamer repeat, VNTRs and the remainder of the sequence (other). C – Illustrates the relationship between VNTR and hexamer repeat length during evolution of the SVA subtypes. The average lengths are shown in base pairs. D – The fold difference in size of each of the central VNTRs from the SVA subtypes in the human genome, and their percentage contribution to form G4 compared to the value for SVA subtype F1 which has the highest value for both central VNTR length and G4 potential of the central VNTR.

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