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Table 1 Distribution of polymorphic mutations in individual viruses isolated from bacteriophage Qβ populations evolved in the presence of AZC

From: Evolution at increased error rate leads to the coexistence of multiple adaptive pathways in an RNA virus

Nt1 1520 1604 2059 2277 2378 2384 2471 2982 3413 3545 3582 3879 3945 3989 4006
Wt2 U C C A C C C A C C U C G U A
Population Qβ-AZC(t60)3
C1 C G . . . . . G U . . . A C .
C2 C . . . . . . G . . . . A C .
C3 C . . . . . . G . . . . A C .
C4 C G . . . . G G . . . . A C .
C5 . . . . . . . . . . . . . . .
C6 . . . . . . . . G . . . . . G
C7 . . . G G . . . . . . . . . .
C8 . . . . . G . . . . . . . . .
C9 . . . . . G G . . . . . . . .
C10 . . . . . . . . . . . . . C .
Population Qβ-AZC(t70)3
C1 C . . . . . . G . . . . A C .
C2 C . G . . . . G . . . . A C .
C3 C . . . . G . G G . . . A C .
C4 . . . . . . . . . . C . . . .
C5 . . . . . . G . . . C . . . .
C6 . . . . . . . . G . C . A C .
C7 . . G . . G . . G . . . . . .
C8 . . . . . . . . G . . . . . .
C9 . . . . . . . . . . . . . . .
C10 . . . . . . G . . . . G . . .
Population Qβ-AZC(t90)3
C1 C . . . . . . G . . . . A C .
C2 C G . . . . G G . A . . A C G
C3 C . G G G . . G . . . . A C .
C4 C G . . . . . G . A . . A C G
C5 C . G . . U . G . . . . A C .
C6 C . G G . . G G . . . . A C .
C7 C . . G . . . G . A . G A C .
C8 C G G . . . G G G A . . A C G
C9 . . . . G . . . . . C G . . .
C10 . . . . G . . . . . C . . . G
C11 . . G G . U . . G . C . A C .
C12 . . . G . G . . . . . . . . .
C13 . G . . G U . . . . . . . . .
C14 C . . G . G . . . . . . A . .
C15 . . . . . . . . G . . G A C .
  1. 1Nucleotide positions where polymorphisms were detected.
  2. 2Nucleotides present at the positions indicated in the wild type virus.
  3. 3Nucleotides present at the positions indicated in the virus clones (indicated as Cx, where x is a number arbitrarily assigned) isolated from that populations. The region sequenced comprises from nucleotide 1485 to nucleotide 4028.