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Table 2 DAVID gene ontology functional annotation enrichment analysis in mechanical simulators

From: Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophilametamorphosis

GBF

ΔT

↓O2

G level

Affected genes (limma raw(FDR))

Behaviour responses

Metamorphosis/morphogenesis/organogenesis

Stress responses

GO clusters observed also in control conditions

 

Reproductive/ mating/oviposition

Sensorial/ hormonal/ odorant prot.

 

Abiotic (heat, light & hypoxia)

Biotic (defense & immune sys.)

Insect cuticle proteins

Cytoesqueleton and cell adhesion

Proteolysis

Red-Ox states/energy

Hemo/ metals/ions binding

RPM

No

No

sim μg UP

218(0)

 

2.9×10 -4

     

3.5×10-2

2.5×10 -6

 
   

sim μg Down

117(0)

  

8.7×10-9

   

2×10-2

  

3.9×10-3

 

Yes

No

sim μg UP

28(0)

 

1.1×10-3

        
   

sim μg Down

17(0)

     

1.9×10-3

    
 

Yes

Yes

sim μg UP

20(0)

          
   

sim μg Down

21(0)

          

LDC

No

No

12g^ UP

85(0)

       

7×10-2

<10 -14

4.2×10-3

   

12g^ Down

63(0)

  

1.7×10-3

  

1×10-3

    
   

6g^ UP

37(0)

  

2.4×10 -5

      

1.1×10-2

   

6g^ Down

8(0)

    

1×10-2

     
 

Yes

No

12g^ UP

873(185)

1.5×10-16

7.9×10-2

3×10 -4

 

1.9×10-8

     
   

12g^ Down

614(72)

     

4.1×10-12

8.9×10 -4

 

5.8×10 -5

5.7×10-3

   

6g^ UP

288(0)

   

3.9×10-2

    

2×10-5

3.7×10-2

   

6g^ Down

118(0)

  

2.9×10-3

2.9×10 -5

2.3×10-2

 

1.7×10-2

  

3.5×10-2

 

No

Yes

12g^ UP

>103(1557)

4.1×10-10

 

5.9×10-15

   

1.2×10 -4

   
   

12g^ Down

>103(1040)

   

4.7×10-3

 

8.4×10-22

  

5.1×10-7

3.4×10-3

   

6g^ UP

>103(1359)

1.3×10-3

 

<10 -15

 

7×10-2

3×10 -6

1.5×10-16

  

5.3×10 -4

   

6g^ Down

912(720)

7.4×10-4

6.8×10-5

 

3.1×10 -6

1.7×10-2

  

1.9×10-9

5.4×10-11

5.8×10-7

 

Yes

Yes

12g^ UP

608(6)

9×10-11

 

3×10-14

5.1×10 -4

3.7×10-3

 

2.8×10-11

  

3.9×10-7

   

12g Down

334(0)

 

5.1×10 -4

      

9.7×10 -5

 
   

6g UP

419(1256)

4.9×10-17

6.1×10-2

3×10-2

 

7.8×10-2

 

3.7×10-2

8×10-2

7×10 -6

 
   

6g Down

297(912)

   

9.6×10-12

  

2.5×10 -4

 

7.7×10-8

7×10 -4

  1. The number of up- or down-regulated probesets in each GBF facility (first column) and condition (column 2 to 4) has been calculated and is shown in the fifth column (filtering with a p-value limma < 0.001, except for the LDC conditions (p-value FDR < 0.05 due to the large number of probesets detected)). Relative enrichment analysis of these gene lists have been done, and the more frequent GO groups observed in experimental (columns 6 to 10), or 1g/environmental controls (columns 11 to 15) are included. Statistically meaningful p values are indicated in the table using italics and bold fonts to emphasize a greater level of enrichment in each particular GO group is observed. ^ indicates the presence of mechanical/rotational disturbances.
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BMC Ecology and Evolution

ISSN: 2730-7182

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