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Figure 1 | BMC Evolutionary Biology

Figure 1

From: DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes

Figure 1

Metabolic pathways involving genes linked to 25-hydroxyvitamin D levels. DHCR7 encodes 7-dehydrocholesterol reductase, which converts 7-dehydrocholesterol to cholesterol, thereby reducing availability for vitamin D synthesis in the skin. CYP2R1 encodes 25-hydroxylase, which converts Vitamin D to 25(OH)D. GC encodes Vitamin D Binding Protein (DBP) which is a glycosylated alpha-globulin that transports vitamin D metabolites from the gut and skin to target end-organs. Proteins linked to 25-hydroxyvitamin D levels are indicated in bold.

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