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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Impact of constitutional copy number variants on biological pathway evolution

Figure 3

CNV-gene frequency heatmaps A. CNV-gene frequency heatmap for Basal transcription factors pathway and example of the significant gene variant association for TAF4B gene from this pathway taken from YRI RNA-seq data. In the heatmap, rows correspond to CNV-gene pairs and columns correspond to three Hapmap populations: YRI, CEU and ASN. The values of the heatmap are CNV polymorphism frequency (see Methods). Evidence for population differentiation is given below the box plots. The schematic diagram shows connection of the gene TFA4B with NF-kB signaling pathway (see text for explanations). B . Example of the significant gene variant association for APOBEC3B gene taken from CEU RNA-seq data. Evidence for population differentiation is given below the box plots. Schematic diagram shows connection of the gene APOBEC3B with Alu/L1 retrotransposition (see text for explanations). C . Examples of CNV-gene frequency heatmaps for four pathways: Apoptosis, Fructose and mannose metabolism, NF-kb signaling pathway and Androgen and estrogen metabolism. Here flanking areas for CNV-gene pairs are 10 kb.

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