Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)

Table 2 Positively (MEME and SLAC-PS) and negatively (SLAC-NS) selected sites detected for the exon 3 of Tlr 4 and Tlr 7 at p < 0.05

	ECD (and LBR)	TD	TIR	ICD-DP
*Tlr* 4	1-635 (248– 469)	636 -658	671 -816	817- 835
MEME	273, 335, 345, 347, 361, 363, 366, 368, 394, 398, 442, 469	-	-	818
SLAC-PS	347, 469
SLAC-NS	99, 105, 149, 240, 253, 364, 457, 461, 463, 518, 522, 529, 549, 616, 635	-	679, 688, 691, 721, 740, 772, 782, 785, 793, 811	822
*Tlr* 7	1-850 (495 –597)	851- 873	894- 1033	1034 -1050
MEME	128, 308, 461, 772	-	-	-
SLAC-PS	308
SLAC-NS	156, 272, 455, 528, 541, 671, 676, 709,	-	963, 971	-

Note. - ECD extracellular domain, LBR ligand binding domain, TD transmembrane domain, TIR TIR domain, ICD-DP distal part of intracellular domain. Prediction of domains and numbering of sites are according to the reference protein sequence of Rattus norvegicus taken from GenBank [NP_062051.1 for Tlr4 and NP_001091051.1 for Tlr7]. Sites located in LBR are underlined.

ISSN: 2730-7182