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Table 3 Evolutionary properties of human proteins of different age

From: Emergence of novel domains in proteins

 

Age

N proteins

Domains/prot.

Protein length*

dN/dSa*

Proteins with domains

     
 

Old

11,039

1.91 (1)

616.3 (473)

0.11 (0.08)

 

Vertebrate

473

1.15 (1)

394.3 (269)

0.21 (0.18)

 

Mammalian

62

1.02 (1)

267.9 (163)

0.35 (0.33)

Proteins without domains

     
 

Old

1,816

NA

654.6 (501)

0.15 (0.12)

 

Vertebrate

851

NA

449.0 (319)

0.21 (0.18)

 

Mammalian

358

NA

308.2 (214.5)

0.39 (0.31)

  1. Mean and median (in brackets) are shown. aNon-synonymous to synonymous substitution rate (dN/dS) was calculated for 10,636 Old, 416 Vertebrate and 40 Mammalian proteins with domains, and for 1,740 Old, 784 Vertebrate and 274 Mammalian proteins without domains. *Kolmogorov-Smirnov test p < 10-5 in all pairwise comparisons.