Skip to main content
Figure 1 | BMC Evolutionary Biology

Figure 1

From: Origin, evolution and classification of type-3 copper proteins: lineage-specific gene expansions and losses across the Metazoa

Figure 1

Domain architecture, copper-binding site alignment and origin of type-3 copper protein subclasses. A. Schematic representation of domain architecture of each type-3 copper protein subclass. SP: signal peptide; CYS: cysteine-rich regions; Cu(A) and Cu(B): copper-binding sites; TM: transmembrane region. B. Sequence alignment of both copper-binding sites from representatives of each type-3 copper protein subclass. Active-site histidine residues, which are important in copper-binding site conformation (blue), and conserved amino acids across all subclasses (yellow), as well as conserved amino acids restricted to specific subclasses (orange) that might have important role in structural conformation. See Additional file 1 for protein nomenclature. C. A simplified phylogenetic tree of the three domains of life showing the emergence of α-, β- and γ-subclasses.

Back to article page