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Table 2 Model comparison: global analysis

From: A mechanistic stress model of protein evolution accounts for site-specific evolutionary rates and their relationship with packing density and flexibility

Potential Model y x AIC w(AIC) R pR
pfANM Stress ω MLmS 191424 1.00 -0.55 -0.32
  Flexibility ω MSF 199645 0.00 0.47 -0.04
ANM Stress ω MLmS 194589 1.00 -0.52 -0.40
  Flexibility ω MSF 207993 0.00 0.36 -0.02
  1. NOTE: Results of global fits for all sites of the dataset. Potential is the ENM potential. Model is either the Stress Model or Flexibility Model. y is in all cases the site-specific rate of evolution inferred using Rate4Site, x is the independent variable of each model. AIC is the Akaike Information Criterion, that quantifies the goodness of fit of a model (the lower the better). w(AIC) is the AIC weight of evidence for each compared model (same ENM). R is Pearson’s correlation coefficient between variables y and x. pR is the partial correlation coefficient when controlling for the x variable of the contrasting model (same ENM). All variables were z-score normalized for each protein before fitting.