Potential

Model

y

x

AIC

w(AIC)

R

pR


pfANM

Stress

ω

MLmS

191424

1.00

0.55

0.32


Flexibility

ω

MSF

199645

0.00

0.47

0.04

ANM

Stress

ω

MLmS

194589

1.00

0.52

0.40


Flexibility

ω

MSF

207993

0.00

0.36

0.02

 NOTE: Results of global fits for all sites of the dataset. Potential is the ENM potential. Model is either the Stress Model or Flexibility Model. y is in all cases the sitespecific rate of evolution inferred using Rate4Site, x is the independent variable of each model. AIC is the Akaike Information Criterion, that quantifies the goodness of fit of a model (the lower the better). w(AIC) is the AIC weight of evidence for each compared model (same ENM). R is Pearson’s correlation coefficient between variables y and x. pR is the partial correlation coefficient when controlling for the x variable of the contrasting model (same ENM). All variables were zscore normalized for each protein before fitting.